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Amgen

Principal Machine Learning Engineer

Amgen

. Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud and on-premises environments .

Posted 9/25/2026full-timeRemote • United StatesLead💰 $187,395 - $253,535 per yearWebsite

Tech Stack

Tools & technologies
AWSAzureCloudDockerGoogle Cloud PlatformJavaKubernetesPython

About the role

Key responsibilities & impact
  • Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud and on-premises environments
  • Build production ML and generative-AI solutions and lightweight applications delivering sub-second insights
  • Build end-to-end ML pipelines covering data ingestion, feature engineering, training, hyperparameter optimization, evaluation, registration, and automated promotion
  • Build and maintain full-stack AI applications integrating model services with UI components, workflow engines, or business-logic layers
  • Establish observability, SLOs, safe deployment practices, and incident runbooks
  • Lead offline/online and A/B evaluation, drift detection, and automated retraining
  • Architect LLM/RAG systems with prompt management, safety guardrails, and optimized inference
  • Enforce data quality, lineage, model cards, and data cards; apply privacy-preserving techniques
  • Contribute reusable ML/GenAI components such as feature stores, model registries, and experiment-tracking libraries
  • Evangelize best practices that improve engineering velocity across squads
  • Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets
  • Prototype and benchmark algorithms, advise on scalability and production readiness, and co-own model-performance KPIs
  • Translate R&D, Manufacturing, and Commercial domain needs into roadmaps
  • Mentor teams and communicate technical trade-offs
  • Partner with DevOps, Security, Compliance, and Product teams to deliver enterprise-grade AI solutions

Requirements

What you’ll need
  • Doctorate degree and 2 years of Machine Learning Engineer experience, OR Master’s degree and 6 years, OR Bachelor’s degree and 8 years, OR Associate’s degree and 10 years, OR high school diploma/GED and 12 years
  • Minimum of 2 years of experience directly managing people and/or leadership experience leading teams, projects, programs, or directing allocation of resources
  • 3–5 years in AI/ML and enterprise software
  • Strong command of machine-learning algorithms, including regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, CNNs, RNNs, transformers, and LLM/RAG techniques
  • Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale
  • Expert knowledge of vector databases, RAG pipelines, prompt-engineering DSLs, and agent frameworks such as LangChain, LangGraph, and Semantic Kernel
  • Proficiency in Python and Java
  • Experience with Docker/Kubernetes containerization
  • Experience with AWS, Azure, or GCP
  • Experience with modern DevOps/MLOps, including GitHub Actions and Bedrock/SageMaker Pipelines
  • Strong business-case skills, including modeling TCO versus NPV
  • Exceptional stakeholder management and ability to translate complex technical concepts into concise, outcome-oriented narratives
  • Biotechnology or pharma industry experience is preferred
  • Published thought-leadership or conference talks on enterprise GenAI adoption preferred
  • Master’s degree in Computer Science and/or Data Science preferred
  • Familiarity with Agile methodologies and SAFe preferred
  • Master’s degree with 10–12+ years of experience in Computer Science, IT, or related field, OR Bachelor’s degree with 12–14+ years of experience in Computer Science, IT, or related field
  • Excellent analytical and troubleshooting skills
  • Strong verbal and written communication skills
  • Ability to work effectively with global, virtual teams
  • High degree of initiative and self-motivation
  • Ability to manage multiple priorities successfully
  • Strong presentation and public speaking skills

Benefits

Comp & perks
  • A comprehensive employee benefits package
  • Retirement and Savings Plan with generous company contributions
  • Group medical, dental and vision coverage
  • Life and disability insurance
  • Flexible spending accounts
  • Discretionary annual bonus program
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible
  • Career development opportunities
  • Work/life balance plans
  • Financial plans with opportunities to save towards retirement or other goals