Senior Principal Scientist, Skin Biology and Inflammation

Amgen

. Provide scientific leadership for discovery programs, technology platforms, or strategic initiatives focused on skin biology and inflammatory disease .

Posted 10/27/2026full-timeSouth San Francisco • California • United StatesSenior💰 $170,569 - $230,769 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in skin biology and inflammatory diseases, leveraging advanced computational and experimental strategies to drive discovery programs. Proven ability to lead cross-functional teams, communicate scientific insights effectively, and influence strategic initiatives within the organization.

Highest-signal resume keywords

Deep Expertise In Keratinocyte BiologyExperience Using AI-Enabled ToolsStrong Record Applying Human TissuesDemonstrated Excellence In Project LeadershipCommitment To Coaching Others

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Human TissuesDisease-Relevant Cellular SystemsOrganotypic ModelsSpatial BiologySingle-Cell MethodsImagingOmicsFunctional GenomicsPerturbational ApproachesDrug Discovery Programs

Soft Skills

Excellent Written Communication SkillsExcellent Verbal Communication SkillsCoaching OthersBuilding An Inclusive Environment

Tools & Technologies

AI-Enabled ToolsMachine LearningComputational BiologyAdvanced AnalyticsData Integration

Certifications & Qualifications

Doctorate Degree (PhD)PharmDMD

Industry Keywords

Skin InflammationEpithelial-Immune CrosstalkWound RepairTissue RemodelingInflammatory Diseases Of The Skin

About the role

Key responsibilities & impact

Provide scientific leadership for discovery programs, technology platforms, or strategic initiatives focused on skin biology and inflammatory disease
Define human-biology-driven hypotheses and translate them into experimental and computational strategies
Design, direct, and interpret complex studies using human tissues and advanced preclinical systems
Apply AI-enabled, computational, agentic, and data-science approaches to synthesize evidence and generate mechanistic insights
Partner with computational scientists, engineers, automation experts, translational scientists, human geneticists, clinicians, and project teams
Identify, evaluate, and implement emerging technologies in skin biology
Guide program strategy, milestone definition, experimental prioritization, risk assessment, and resolution of complex scientific issues
Influence project, departmental, and broader functional strategy
Lead and contribute to cross-functional teams
Coach and provide scientific and technical guidance to colleagues
Communicate scientific strategy, evidence, uncertainty, and recommendations to project teams, senior leaders, governance bodies, and external scientific audiences
Build external scientific eminence through collaborations, conferences, publications, patents, and other scientific or technical outputs

Requirements

What you’ll need

Doctorate degree (PhD), or PharmD, or MD and relevant post-doc where applicable and 3 years of relevant experience, or Master’s degree and 6 years of relevant experience, or Bachelor’s degree and 8 years of relevant experience
Deep expertise in keratinocyte biology, stromal or fibroblast biology, skin inflammation, epithelial-immune crosstalk, wound repair, tissue remodeling, and/or inflammatory diseases of the skin
Strong record applying human tissues, disease-relevant cellular systems, organotypic models, spatial biology, single-cell methods, imaging, omics, functional genomics, or perturbational approaches
Experience using AI-enabled tools, machine learning, computational biology, agentic research workflows, advanced analytics, or data integration
Ability to identify technology opportunities and build partnerships and workflows that convert concepts into robust capabilities
Experience advancing drug discovery programs and connecting target biology to modality, biomarkers, translational strategy, clinical differentiation, and portfolio value
Evidence of scientific influence beyond an immediate team
Excellent written and verbal communication skills
Demonstrated excellence in project leadership and operational execution
Commitment to coaching others and building an inclusive environment

Benefits

Comp & perks

Comprehensive employee benefits package
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible
Career development opportunities
Work/life balance support