Director, Pharmacometrics

Avenzo Therapeutics

. Lead development and execution of pharmacometrics strategies supporting oncology programs .

Posted 10/7/2026full-timeSan Diego • California • United StatesLead💰 $234,000 - $250,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in pharmacometrics and clinical pharmacology, with a strong focus on population PK/PD modeling, regulatory submissions, and strategic leadership in oncology drug development. Proficient in managing cross-functional teams and delivering complex analyses to support dosing strategies and regulatory decision-making.

Highest-signal resume keywords

PhD In PharmacometricsPopulation PK/PD ModelingNONMEM ExpertiseOncology Drug DevelopmentRegulatory Submissions

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Pharmacometric ModelingExposure-Response AnalysisClinical Pharmacology PlansDosing StrategiesStatistical Analysis

Soft Skills

Excellent CommunicationInterpersonal SkillsAnalytical AbilitiesProblem-Solving SkillsStrategic Mindset

Tools & Technologies

NONMEMMonolixRModeling EnvironmentsSimulation Tools

Industry Keywords

Pharmaceutical SciencesBiostatisticsIND FilingsNDA FilingsMAA Filings

About the role

Key responsibilities & impact

Lead development and execution of pharmacometrics strategies supporting oncology programs
Apply population PK, PK/PD, exposure-response modeling, and simulation analyses to guide dose optimization, study design, and regulatory decision-making
Provide strategic leadership and subject matter expertise in pharmacometrics and clinical pharmacology
Lead pharmacometric activities on cross-functional program teams with Clinical Development, Biometrics, Regulatory Affairs, and internal and external experts
Develop analyses supporting dosing recommendations for special populations, dose modifications, drug–drug interactions, organ impairment, and other factors
Resolve complex scientific and technical challenges affecting multiple programs
Analyze and interpret clinical and translational PK/PD data and oversee pharmacometric modeling
Develop clinical pharmacology plans and dosing strategies from first-in-human through late-stage clinical development
Author and review clinical pharmacology content for protocols, clinical study reports, regulatory submissions, briefing documents, and health authority interactions
Represent Clinical Pharmacology and Pharmacometrics in regulatory agency meetings and responses
Oversee pharmacometric platforms, modeling environments, reporting workflows, and external vendors
Manage pharmacometrics activities, budgets, timelines, and deliverables
Influence development strategy through quantitative analyses and scientific recommendations
Report to the VP, Clinical Pharmacology

Requirements

What you’ll need

PhD degree in pharmacometrics, biological/pharmaceutical sciences, bioengineering, biostatistics, engineering, data science, or a related discipline, with 8+ years of progressive pharmacometrics experience in the life sciences industry, or equivalent combination of academic and industry experience
Expertise in population PK/PD, exposure-response, and model-informed drug development approaches
Extensive hands-on experience with NONMEM, Monolix, R, and other industry-standard modeling and simulation tools
Deep understanding of clinical pharmacology and pharmacometric requirements for IND, NDA, MAA, and NDS filings
Experience leading and authoring modeling and simulation plans and directing pharmacometric analyses across Phase I–IV clinical development programs
Strong knowledge of oncology drug development, clinical pharmacology principles, and regulatory guidelines
Ability to manage multiple priorities, projects, and deliverables through influence, matrix leadership, and stakeholder engagement
Excellent communication and interpersonal skills
Strong analytical and problem-solving abilities with a strategic mindset
Willingness to travel periodically/regularly, including up to 15% of work time, potentially overnight
Remote employees must travel to and work from the company headquarters in San Diego from time to time
San Diego-based employees must work on-site Monday through Thursday

Benefits

Comp & perks

Medical, dental, vision, and basic life and AD&D insurance
Short-term and long-term disability insurance
Flexible spending accounts
Health savings accounts
Voluntary life, AD&D accident, and critical illness insurance programs
401(k) plan
10 hours of paid vacation time accrued every month
1 hour of paid sick leave accrued for every 30 hours worked
17 paid holidays each calendar year, including a winter closure
Annual discretionary bonus
Equity award
Remote home office arrangement for remote employees
Periodic travel and work from company headquarters for remote employees