Principal Scientist, Mass Spectrometry

BeOne Medicines

. Contribute to the scientific direction of BeOne Institute by identifying and advancing high-impact research opportunities .

Posted 10/13/2026full-timeSan Carlos • California • United StatesLead💰 $165,300 - $206,600 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates deep expertise in mass spectrometry and analytical chemistry, with a strong ability to design and execute complex research programs that address biological questions. Proficient in data analysis and interpretation, with experience in developing mass spectrometry-based workflows and collaborating across multidisciplinary teams.

Highest-signal resume keywords

Mass Spectrometry ExpertiseLC-MS Instrumentation OptimizationQuantitative ProteomicsData Analysis and InterpretationCross-Disciplinary Collaboration

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Mass SpectrometryProteomics WorkflowsSample PreparationChromatography MethodsData Analysis SoftwareAnalytical ChemistryBiological Pathway InterrogationMechanistic InsightsTroubleshooting Analytical ChallengesMS-Based Screening

Soft Skills

Excellent CommunicationPresentation SkillsCreative Problem Solving

Tools & Technologies

Orbitrap SystemsAgilent Q-TOFsData Acquisition SoftwareAnalytical Workflows

Industry Keywords

Cancer PathwaysASMS WorkflowsAPMS WorkflowsCompound DiscoveryTarget Identification

About the role

Key responsibilities & impact

Contribute to the scientific direction of BeOne Institute by identifying and advancing high-impact research opportunities
Design and execute research programs using mass spectrometry to address biological questions and enable therapeutic modalities
Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows
Support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation
Evaluate and implement emerging mass spectrometry technologies, workflows, and applications
Lead operation and continuous advancement of mass spectrometry platforms
Analyze and interpret complex mass spectrometry datasets and translate results into actionable insights
Partner with biology, chemistry, and other scientists on multidisciplinary research programs
Maintain experimental records and documentation
Stay current with advances in mass spectrometry and analytical technologies
Serve as a contact for external CRO partners when needed
Provide matrix or line-function leadership for project teams when needed

Requirements

What you’ll need

Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline
6+ years of relevant experience with a Ph.D., 8+ years with an M.S., or 10+ years with a B.S.
Deep expertise in mass spectrometry
Hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation
Experience developing and implementing mass spectrometry-based screening and proteomics workflows
Ability to apply mass spectrometry to complex biological questions and generate mechanistic insights
Experience with quantitative proteomics and/or MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation
Experience developing and optimizing sample preparation, chromatography, and MS methods
Strong data analysis and interpretation skills for complex mass spectrometry datasets
Ability to independently troubleshoot analytical challenges and develop creative solutions
Ability to partner with scientists across biology, chemistry, and other disciplines
Excellent communication and presentation skills
Proficiency with mass spectrometry data acquisition, processing, and analysis software
Strong computational and data analysis skills
Experience with software and tools for MS-based screening and assay development
Ability to work on-site in San Carlos, CA
Experience with Orbitrap systems and Agilent Q-TOFs strongly preferred
Knowledge of cancer pathways preferred
Experience with ASMS and APMS workflows preferred

Benefits

Comp & perks

Annual bonus plan eligibility for non-commercial roles
Discretionary equity awards
Voluntary participation in the Employee Stock Purchase Plan
Medical insurance
Dental insurance
Vision insurance
401(k)
FSA/HSA
Life insurance
Paid Time Off
Wellness program