Senior Principal Engineer, EMES Developer

Bristol Myers Squibb

. Develop, maintain, and support the global Enterprise Manufacturing Execution Systems (EMES) solution used across the digital manufacturing network .

Posted 10/22/2026full-timeUnited StatesSenior💰 $158,870 - $211,758 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive experience in developing and supporting Enterprise Manufacturing Execution Systems (EMES) within the Life Sciences industry, with a strong focus on software validation, regulatory compliance, and automation solutions. Proficient in programming languages and database management, with a proven ability to collaborate across global teams.

Highest-signal resume keywords

Enterprise Manufacturing Execution Systems (EMES)Software ValidationAutomation and Execution SystemsSQL Server SkillsLife Sciences Industry Experience

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

VBScriptPowerShellPythonJavaScriptSQL ServerSyncadeDeltaVPI Data HistorianDatabase AdministrationQuery Optimization

Soft Skills

CollaborationMentoringContinuous ImprovementProblem SolvingCross-Cultural Communication

Tools & Technologies

MSMQKafkaRabbitMQSAPLIMS

Industry Keywords

Regulated ManufacturingData IntegrityManufacturing ProcessesIT Tools and SystemsEnterprise System Integration

Tech Stack

Tools & technologies

JavaScriptKafkaPythonRabbitMQSQL

About the role

Key responsibilities & impact

Develop, maintain, and support the global Enterprise Manufacturing Execution Systems (EMES) solution used across the digital manufacturing network
Partner with IT and Business teams to understand requirements and develop solutions
Design, build, test, and deliver standard and custom EMES capabilities globally
Support the EMES solution to minimize manufacturing disruption and product impact
Support administration of central EMES development and test systems, with oversight of site development, test, and production systems
Contribute to knowledge management through content generation and mentoring
Identify and execute continuous-improvement opportunities
Promote compliance with data integrity and computer system validation requirements and regulations
Assess changes and their impact on the validated state of applications and underlying infrastructure
Support EMES core platform, components, interfaces, custom tools, and customizations covering material and inventory, order management, equipment and instrument integration, sample management, patient scheduling integration, label printing, recipe functionality, batch reporting, and analytics

Requirements

What you’ll need

Bachelor of Science in Engineering, Computer Science (preferred) or related fields
10+ years’ experience in the Life Sciences industry, with at least 8 years’ experience in MES
At least 5 years’ direct experience designing, building, deploying and supporting automation and execution systems such as Syncade, DeltaV, and PI Data historian in regulated manufacturing environments
Strong domain expertise in applying IT to manufacturing and understanding manufacturing processes and supporting IT tools and systems
Strong knowledge of the regulatory landscape and demonstrated experience with software validation
Proven track record of successful IT/automation solution delivery
Proficiency in VBScript, PowerShell, Python, or JavaScript
Strong SQL Server skills, including query optimization, complex querying, and database administration
Knowledge of message-oriented middleware and event-driven systems, including MSMQ, Kafka, RabbitMQ, or similar technologies
Experience in enterprise system integration, preferably involving SAP, LIMS, and MES platforms
Ability to work across global sites and cultures
Optional travel up to 5% domestically and internationally

Benefits

Comp & perks

Comprehensive benefit plans including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life and disability insurance offerings
U.S.-based exempt employees: Flexible Time Off (FTO) without a set accrual limit, subject to manager approval
11 paid company holidays each year
Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico: 160 hours of paid vacation annually for new hires
3 optional holidays for non-exempt employees, RayzeBio employees, and employees located in Puerto Rico
Additional time-off benefits may include paid sick leave
Up to two paid volunteer days per year
Summer hours flexibility
Leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
Annual Global Shutdown between Christmas Day and New Year's Day for eligible employees
Additional discretionary incentive cash and stock opportunities may be available