Director, Tax

Definium Therapeutics

. Develop and execute Definium's tax strategy as the company transitions from development-stage to commercial-stage operations .

Posted 11/6/2026full-timeNew York City • New York • United StatesLead💰 $200,000 - $290,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in tax strategy development and execution, particularly in ASC 740 tax accounting and U.S. corporate taxation. Proven ability to manage tax compliance, support public company reporting, and lead cross-functional collaboration in a commercial-stage environment.

Highest-signal resume keywords

ASC 740 Tax AccountingTax Strategy DevelopmentCPA CertificationProgressive Tax ExperienceProject Management

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Tax ComplianceNOL PlanningR&D CreditsMulti-State TaxationEquity CompensationCapital Markets TransactionsTax Attributes ManagementTax Readiness for CommercializationFederal and State Tax StudiesValuation Allowances

Soft Skills

Organizational SkillsCommunication SkillsStrategic Thinking

Certifications & Qualifications

CPA CertificationMaster's in Taxation (MST)

Industry Keywords

BiotechPharmaceuticalLife SciencesHealthcarePublic Company ReportingBig Four Accounting ExperienceDevelopment-Stage to Commercial Operations

About the role

Key responsibilities & impact

Develop and execute Definium's tax strategy as the company transitions from development-stage to commercial-stage operations
Lead tax strategy and planning, including tax impacts of financings, equity compensation, corporate structure changes, and strategic transactions
Own ASC 740 tax accounting, including quarterly and annual provisions, deferred tax assets, valuation allowances, and uncertain tax positions, supporting SEC reporting and audits
Oversee federal, state, local, and international tax compliance performed by external providers and coordinate responses to tax authority inquiries
Lead tax readiness for commercialization, including state and local, sales and use, franchise, and nexus considerations for a growing field-based and commercial workforce
Manage tax attributes and credits, including Section 382 analyses, NOL preservation, and federal and state R&D credit studies
Support business development, licensing, collaboration transactions, transfer pricing, and legal entity planning
Serve as principal liaison to external tax advisors, managing workstreams, budgets, and deliverables
Partner with Accounting, FP&A, Treasury, Legal, Payroll, HR, Commercial, and Executive Leadership
Build scalable tax processes, policies, and documentation

Requirements

What you’ll need

Minimum bachelor's degree in accounting, Finance, Tax, or a related field required
CPA certification required
Minimum 10 years of progressive tax experience required
Strong knowledge of ASC 740 and U.S. corporate taxation required
Experience supporting public company reporting and managing external tax service providers required
Strong project management, organizational, and communication skills, with the ability to balance strategy and hands-on execution
Up to 10% travel required based on business needs
Master's in Taxation (MST) or advanced tax credential preferred
Big Four or national public accounting experience preferred
Biotech, pharmaceutical, life sciences, or healthcare industry experience preferred
Experience supporting organizations transitioning from development-stage to commercial operations preferred
Experience with Section 382, NOL planning, R&D credits, multi-state taxation, equity compensation, and capital markets transactions preferred

Benefits

Comp & perks

Bonus eligibility
Equity opportunities
Health insurance
401(k) with company match
Flexible time off
Wellness benefits and perks