Principal Software Engineer

eClinical Solutions

. Design, develop, test, and deploy scalable, secure, and highly interactive web applications .

Posted 9/21/2026full-timeMansfield • Massachusetts • United StatesLead💰 $152,000 - $190,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in designing, developing, and deploying scalable web applications using the Microsoft technology stack, with a strong focus on AI integration and secure development practices. Proven ability to lead technical initiatives, mentor engineers, and ensure compliance with industry standards.

Highest-signal resume keywords

C#.NETASP.NETAngularAI Integration

ATS Keywords

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Hard Skills

Software DesignFull-Stack Web DevelopmentSQLMicroservicesDistributed SystemsAgile MethodologiesPrompt EngineeringPerformance TuningTechnical DocumentationWorkflow Automation

Soft Skills

CommunicationTechnical LeadershipCollaborationMentorshipProblem-Solving

Tools & Technologies

OpenAIAzure OpenAIAWSPythonHTMLCSSTypeScript

Industry Keywords

EClinical SolutionsLife SciencesRegulated SaaSClinical Trial DataSecure Development

Tech Stack

Tools & technologies

AngularASP.NETAWSAzureCloudDistributed SystemsMicroservicesPythonSDLCSQLTypeScript.NET

About the role

Key responsibilities & impact

Design, develop, test, and deploy scalable, secure, and highly interactive web applications
Own and evolve core platform modules from concept through release and support
Influence application and system architecture with focus on performance, reliability, security, and maintainability
Lead by example through clean, well-tested code, design reviews, and pragmatic technical decisions
Collaborate with Product Management, QA, and other engineers throughout the SDLC
Provide technical mentorship and guidance to other engineers
Diagnose and resolve complex production issues across distributed systems
Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
Contribute to technical documentation including design specs, acceptance criteria, and release notes
Integrate LLMs and AI services into .NET- and Python-based systems
Design and implement AI-assisted workflows, copilots, and intelligent automation features
Work with agentic AI patterns such as task orchestration, tool-using agents, and workflow automation
Apply prompt engineering, evaluation techniques, and guardrails for reliability and compliance
Collaborate with data and platform teams to operationalize AI in production-grade systems

Requirements

What you’ll need

Bachelor’s or Master’s degree in Computer Science or equivalent practical experience
10+ years in software design and development using the Microsoft technology stack preferred
Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
Strong experience building full-stack web applications using Angular, TypeScript, HTML, and CSS
Solid understanding of software design principles, patterns, and best practices
Experience across the full Software Development Lifecycle (Agile preferred)
Ability to work independently while collaborating effectively in a fast-paced environment
Excellent communication, documentation, and technical leadership skills
Hands-on experience integrating LLM-based services such as OpenAI or Azure OpenAI into applications
Experience using Python and/or .NET alongside AI/LLM workflows
Understanding of secure and responsible AI usage in enterprise systems
Familiarity with agent-based or workflow-driven AI architectures is a strong plus
Strong SQL expertise, including performance tuning, is nice to have
Experience with microservices, distributed systems, and cloud platforms such as AWS is nice to have
Secure development experience, including awareness of common vulnerabilities and mitigations, is nice to have
Experience with clinical trial data, life sciences, or regulated SaaS environments is nice to have
Experience building data visualizations or analytics-driven user experiences is nice to have

Benefits

Comp & perks

Work-life balance
Inclusive culture
Opportunities to learn, grow, and continuously improve
Career and skills development within a fast-growing company
Equal opportunity employment