Senior Medical Director, Clinical Development

Editas Medicine

. Lead the design, medical oversight, and operational execution of clinical development strategies for EDIT-401, emphasizing early development and translational endpoints relevant to gene editing.

Posted 10/8/2026full-timeCambridge • Massachusetts • United StatesSenior💰 $345,000 - $375,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical development strategies, particularly in gene editing and cardiovascular diseases, with a strong focus on regulatory compliance and data integrity. Proven ability to lead cross-functional teams and collaborate effectively with global stakeholders to execute high-quality clinical trials.

Highest-signal resume keywords

MD Or MD/PhD10+ Years Industry ExperienceClinical Trial MethodologyGene Editing ExperienceExceptional Communication Skills

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Development StrategiesGlobal Clinical Trials DesignTranslational ScienceSafety MonitoringClinical Trial ExecutionStudy Protocol DevelopmentIND/CTA/NDA/BLA DocumentationBiomarker DevelopmentRisk AssessmentData Review

Soft Skills

LeadershipCollaborationInfluencing SkillsStrategic ThinkingNetwork Building

Industry Keywords

Cardiovascular DiseasesRare DiseaseBiotech EnvironmentClinical ResearchRegulatory PathwaysCRO CollaborationScientific Advisory BoardsKOL EngagementPatient AdvocacyHigh-Growth Environment

About the role

Key responsibilities & impact

Lead the design, medical oversight, and operational execution of clinical development strategies for EDIT-401, emphasizing early development and translational endpoints relevant to gene editing.
Serve as clinical program lead, providing day-to-day medical and scientific leadership to ensure high-quality clinical execution and data integrity.
Partner with R&D to integrate biomarker strategy, safety monitoring approaches, and indication rationale.
Develop and refine clinical development plans and study protocols aligned with global regulatory expectations.
Support clinical documents for IND, CTA, NDA/BLA components, and study reports, focusing on medical content and scientific rationale.
Collaborate with regulatory affairs and region-specific experts for global regulatory agency interactions.
Coordinate with Clinical Operations, Regulatory, Project Management, CMC, Analytical Sciences, and Commercial for integrated planning and execution.
Partner with Research teams on indication selection, biomarker development, and new pipeline programs.
Provide clinical leadership in cross-functional forums, risk assessments, data reviews, and stage-gate processes.
Cultivate networks with global investigators, KOLs, and patient advocacy groups.
Lead or support scientific advisory boards, investigator meetings, and data-review interactions.
Represent the company at scientific conferences and contribute to manuscripts, abstracts, and presentations.

Requirements

What you’ll need

MD or MD/PhD with training in cardiovascular diseases, internal medicine, rare disease, or related fields.
10+ years of industry experience in clinical research and development, including leadership of early-stage cardiovascular disease and/or rare disease programs.
Demonstrated experience designing and executing global clinical trials; experience with gene-editing, gene therapy, or advanced modalities is a plus.
Hands-on experience establishing or overseeing clinical trials, including collaboration with local CROs, investigators, and hospital partners.
Willingness to travel to develop and oversee global clinical trials.
Strong understanding of clinical trial methodology, translational science, safety monitoring, and global regulatory pathways.
Proven ability to work effectively in matrixed teams and influence across scientific, operational, and business stakeholders.
Exceptional written and verbal communication skills, including experience presenting to investigators, regulators, and internal governance bodies.
Strategic, pragmatic, and able to thrive in a high-growth, mission-driven biotech environment.
Strong network of clinical investigators and scientific collaborators globally, enabling effective partnership-building, and study execution.

Benefits

Comp & perks

Blue Cross Blue Shield PPO Medical Plan
Company-funded Health Savings Account
Dental and Vision Insurance
Life and Disability Insurance
Dependent Care Account
Tuition Reimbursement
401(k) plan with company match
Employee Assistance Plan
Wellness Programs
Flexible Paid Time Off policy