Principal Scientist, In Vivo Pharmacology, Neurology

GondolaBio

. Design and execute in vivo pharmacology studies across Neurology programs in rodents and non-human primates toward IND submission .

Posted 10/2/2026full-timeRemote • California • United StatesLead💰 $173,000 - $205,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in designing and executing in vivo pharmacology studies, particularly in Neurology programs, with a strong focus on data analysis, regulatory report writing, and managing CRO relationships. Proficient in pharmacodynamic assessments and familiar with IND-enabling studies in a fast-paced biotech environment.

Highest-signal resume keywords

In Vivo PharmacologyPharmacodynamic AssessmentsCRO ManagementRegulatory Report WritingNeurology Model Characterization

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Applicant Tracking System Keywords

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Hard Skills

Pharmacology Study DesignData AnalysisPK/BioanalysisQPCRWestern BlotELISATest Article DosingTissue ProcessingAntisense Oligonucleotides (ASOs)Rare Disease Models

Soft Skills

Intellectual CuriosityCross-Functional CollaborationIndependent OperationRisk IdentificationEffective Communication

Industry Keywords

Biopharmaceutical IndustryIND SubmissionTranslational TeamsQuality ControlEmerging Study RisksDevelopmental and Epileptic Encephalopathy (DEE)Scientific Community EngagementFast-Moving Biotech Environment

About the role

Key responsibilities & impact

Design and execute in vivo pharmacology studies across Neurology programs in rodents and non-human primates toward IND submission
Partner with toxicology and translational teams to ensure rigorous, reproducible, and translatable in vivo pharmacology data
Inform dose selection and go/no-go decisions
Develop and implement pharmacodynamic and efficacy assessments
Troubleshoot assays and quality-control data from CROs and external partners
Manage CRO relationships and monitor study progress
Identify emerging study risks and present progress updates in team meetings
Analyze in vivo pharmacology endpoints, including PK/bioanalysis and pharmacodynamic and/or efficacy endpoints

Requirements

What you’ll need

Bachelor's degree and 6+ years of biopharmaceutical industry experience within in vivo pharmacology
Experience with small molecules and antisense oligonucleotides (ASOs) preferred
Experience in rare disease or developmental and epileptic encephalopathy (DEE) models strongly preferred
Strong intellectual curiosity, including routine engagement with the scientific community and familiarity with literature
Direct experience and willingness to design pharmacology studies and lead coordination of external efforts
Exposure to IND-enabling studies
Experience writing regulatory or technical reports
Ability to operate independently and cross-functionally in a lean, fast-moving biotech environment
Experience with rodent Neurology model characterization, test article dosing, tissue processing, qPCR, Western blot, and ELISA
Ability to drive work through CROs and external partners

Benefits

Comp & perks

Patient Days to hear directly from individuals living with relevant conditions
Access to learning and development resources
Robust and market-competitive compensation and benefits package including performance bonus, equity, health, welfare, and retirement programs
Flexible PTO
Rapid career advancement for strong performers
Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas
Commitment to Diversity, Equity & Inclusion