Associate Medical Director – Medical Director

Korro Bio, Inc.

. Provide medical leadership for clinical programs, initially KRRO-121, a Phase 1 program for hyperammonemia in urea cycle disorders .

Posted 10/9/2026full-timeCambridge • Massachusetts • United StatesLead💰 $175,000 - $250,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical program leadership, particularly in early-phase studies, with a strong focus on safety review, regulatory compliance, and scientific writing. Possesses the ability to integrate complex data and collaborate effectively with cross-functional teams and external stakeholders.

Highest-signal resume keywords

Medical LeadershipClinical Development ExperienceRegulatory Document AuthorshipFirst-In-Human TrialsICH GCP Knowledge

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Program LeadershipSafety Data ReviewAdverse Event AssessmentProtocol DevelopmentData InterpretationDose EscalationRegulatory SubmissionsClinical Trial DesignMedical MonitoringScientific Writing

Soft Skills

Collaborative Working StyleJudgment in Medical DecisionsFlexibility Across Programs

Certifications & Qualifications

MD or DOBoard Certification in Internal MedicineBoard Certification in PediatricsBoard Certification in Medical GeneticsBoard Certification in GastroenterologyBoard Certification in Hepatology

Industry Keywords

Urea Cycle DisordersHyperammonemiaRare DiseaseInborn Errors of MetabolismRNA-Targeted TherapeuticsGalNAc-Conjugated AgentsFDA RequirementsEMA RequirementsIND ContentCTA Content

About the role

Key responsibilities & impact

Provide medical leadership for clinical programs, initially KRRO-121, a Phase 1 program for hyperammonemia in urea cycle disorders
Act as medical lead and medical monitor for first-in-human and early patient studies
Review eligibility questions, protocol deviations, safety data, and laboratory data
Assess adverse events, serious adverse events, laboratory abnormalities, causality, expectedness, and dose-limiting toxicities
Serve on Safety Review Committees and support dose escalation and cohort progression decisions
Author and review protocols, informed consent forms, Investigator’s Brochures, safety monitoring plans, clinical study reports, and regulatory submissions
Prepare for and present clinical content at meetings with FDA, EMA, and other health authorities
Contribute to clinical development plans, target product profiles, indication expansion strategy, endpoint selection, patient population definition, and dose selection rationale
Build relationships with investigators, key opinion leaders, and patient advocacy organizations
Lead scientific advisory boards and investigator meetings
Deliver protocol and medical training to sites and CRO staff
Partner with Clinical Operations, Biostatistics, Data Management, Clinical Pharmacology, Regulatory Affairs, Toxicology, and Drug Safety
Provide medical input into case report form design, data review, interim and final analyses, and interpretation of results
Provide medical oversight of CRO medical monitoring and safety services
Present emerging clinical findings to program teams, executive leadership, scientific advisory boards, and external audiences
Contribute to abstracts, presentations, manuscripts, portfolio evaluations, and business development due diligence
At Medical Director level, lead clinical strategy, represent Clinical Development in governance forums, and lead health authority interactions
Travel to investigational sites, investigator meetings, and scientific congresses, including international travel, up to 25%

Requirements

What you’ll need

MD or DO, or international equivalent, with completed residency training
At least 2 years of industry clinical development experience for Associate Medical Director; at least 5 years for Medical Director
Prior accountability as medical monitor on early-phase studies
Authorship of protocols and regulatory documents
Direct experience with first-in-human and early-phase clinical trials
Experience with dose escalation, safety review committees, and dose-limiting toxicity assessment
Working knowledge of ICH GCP and FDA and EMA requirements for early clinical development
Knowledge of IND and CTA content
Strong scientific writing and data interpretation skills
Ability to integrate safety, pharmacokinetic, and biomarker data
Board certification or eligibility in internal medicine, pediatrics, medical genetics, gastroenterology or hepatology, or a related specialty preferred
Clinical or development experience in rare disease, inborn errors of metabolism, hepatology, or genetic medicines strongly preferred
Familiarity with urea cycle disorders, hyperammonemia, or hepatic encephalopathy a plus
Experience with oligonucleotide, siRNA, or other RNA-targeted therapeutics, including GalNAc-conjugated agents, a plus
Experience with early-phase studies outside the United States a plus
Collaborative working style suited to a small company
Judgment to make and own medical decisions
Flexibility to work across multiple programs, sites, and time zones

Benefits

Comp & perks

Equity-based compensation
Medical insurance
Dental insurance
Vision insurance
401(k) retirement plan
Life insurance
Dependent care flexible spending account
Company-funded health savings account
Free parking