Principal Program Manager, Enterprise Integration

McKesson

. Lead enterprise-wide, cross-functional integration and modernization programs from strategy through execution, ensuring on-time, on-budget, and high-quality delivery .

Posted 9/22/2026full-timeUnited StatesLead💰 $170,100 - $283,500 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive experience in leading enterprise-wide technology transformation programs, focusing on integration platforms, cloud migration, and portfolio governance. Proven ability to manage complex cross-functional initiatives while ensuring compliance with regulatory standards and optimizing vendor relationships.

Highest-signal resume keywords

IT Program ManagementMuleSoft Platform EvolutionCloud MigrationVendor Relationship ManagementRegulatory Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Enterprise TransformationIntegration PlatformsMiddleware ModernizationAPI IntegrationFinancial PlanningTechnology Portfolio LeadershipBusiness Case DevelopmentROI AnalysisTotal Cost of Ownership OptimizationCapacity Planning

Soft Skills

Executive CommunicationStakeholder ManagementGovernanceRisk Management

Tools & Technologies

IBM MQIBM MFTSAP BODSAzureGCPBoomiIntegration-as-a-ServiceMiddleware Technologies

Certifications & Qualifications

PMPPgMPSAFeAgileITIL

Industry Keywords

Enterprise Architecture GovernanceITGCSOXHIPAADSCSA

Tech Stack

Tools & technologies

AzureCloudGoogle Cloud PlatformPMP

About the role

Key responsibilities & impact

Lead enterprise-wide, cross-functional integration and modernization programs from strategy through execution, ensuring on-time, on-budget, and high-quality delivery
Drive transformation initiatives including MuleSoft platform evolution, middleware modernization, cloud migration, IBM MFT/MQ modernization, SAP BODS upgrades, and Integration-as-a-Service strategies
Develop and manage multi-year program roadmaps, dependencies, risks, and delivery metrics across technology and business organizations
Establish portfolio governance and executive reporting frameworks covering program health, outcomes, value realization, and investment priorities
Lead strategic vendor and managed services relationships, including performance management, capacity planning, SOW governance, KPI tracking, and resource optimization
Drive platform rationalization and Total Cost of Ownership optimization through technology lifecycle planning, licensing strategy, and vendor negotiations
Partner with the Enterprise Architecture Review Board, security, compliance, and audit teams to ensure enterprise standards and regulatory requirements
Align senior stakeholders across Enterprise & Corporate, NAPD, MMS, CMM, and Technology leadership organizations to achieve strategic business objectives

Requirements

What you’ll need

13+ years of experience in IT program management, enterprise transformation, integration platforms, cloud migration, or technology portfolio leadership
Bachelor's degree in Information Technology, Computer Science, Engineering, Information Systems, Business, or a related field, or equivalent experience
Experience with MuleSoft, IBM MQ, IBM MFT, SAP BODS, Azure, GCP, API integration platforms, or enterprise middleware technologies
Experience leading large-scale, enterprise-wide technology transformation programs with executive-level visibility
Proven experience managing complex cross-functional portfolios involving architecture, engineering, operations, security, and business stakeholders
Experience managing budgets, forecasts, financial planning, and portfolio investment decisions
Experience working with enterprise integration technologies, middleware platforms, APIs, cloud migration initiatives, or application modernization programs
Demonstrated experience overseeing external partners, managed service providers, or strategic technology vendors
Strong executive communication, stakeholder management, governance, and risk management capabilities
Experience supporting compliance and audit requirements including ITGC, SOX, HIPAA, DSCSA, or similar regulatory frameworks
Experience developing business cases, ROI analyses, and TCO-based investment recommendations
Strong experience managing vendor relationships
Strong experience working with the Boomi platform
Experience leading cloud migration and modernization programs in highly regulated environments
Knowledge of enterprise architecture governance and EARB processes
Strong understanding of platform operating models, capacity planning, resource management, and technology portfolio governance
PMP, PgMP, SAFe, Agile, ITIL, or comparable program management certifications preferred
Experience leading geographically distributed teams and large-scale managed services engagements

Benefits

Comp & perks

Competitive compensation package as part of Total Rewards
Annual bonus may be offered
Long-term incentive opportunities may be offered
Equal employment opportunities
Reasonable accommodation support for job search or application