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MSD

Principal Scientist – Clinical Research, Immunology Biomarker Lead

MSD

. Lead and shape integrated biomarker strategies across discovery and early- and late-stage clinical programs .

Posted 10/8/2026full-timeUnited StatesSenior💰 $190,800 - $300,300 per yearWebsite

Core Competencies

Role fit
Core Competencies

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Demonstrates expertise in leading biomarker strategies and integrating scientific perspectives to inform clinical development decisions. Proficient in advanced data analytics, biostatistics, and communication of complex insights to diverse stakeholders.

Highest-signal resume keywords
PhD Or MD In ImmunologyExperience In Autoimmune Diseases R&DDeep Expertise In ImmunologyStrong Analytical And Problem-Solving CapabilitiesExperience Advancing Precision Medicine Strategies

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills
Biomarker Strategy DevelopmentTranslational MedicineClinical Development Decision-MakingBiostatisticsBioinformaticsAdvanced Data AnalyticsImmunology ExpertiseRheumatology ExperienceGastrointestinal Inflammation ExperienceDermatology Experience
Soft Skills
Excellent Communication SkillsLeadership In Matrixed Teams
Industry Keywords
Biomarker AnalysisIntegrated Biomarker StrategiesPatient SelectionGovernance ForumsComplex DatasetsKey Opinion Leader InteractionsScientific AudiencesPortfolio StrategyInnovative Biomarker ApproachesDisease Biology

About the role

Key responsibilities & impact
  • Lead and shape integrated biomarker strategies across discovery and early- and late-stage clinical programs
  • Serve as biomarker strategy lead within cross-functional program teams
  • Represent multidisciplinary teams in governance forums
  • Inform portfolio strategy through biomarker-driven insights for target validation, patient selection, and go/no-go decisions
  • Translate disease biology and therapeutic mechanism of action into clinically actionable biomarker strategies
  • Drive selection and application of innovative biomarker approaches
  • Lead biomarker sub-teams and working groups across clinical, discovery, translational, regulatory, biostatistics, and data sciences
  • Integrate diverse scientific perspectives into cohesive strategies
  • Champion biomarker analysis plans and interpret complex datasets
  • Communicate insights to internal stakeholders, governance bodies, and external scientific audiences
  • Support publications, presentations, and key opinion leader interactions

Requirements

What you’ll need
  • PhD or MD in Immunology, Biology, or related STEM degree with 7+ years of experience in Immunology; or MS and 10+ years of experience; or BS and 14+ years of experience
  • Autoimmune Diseases R&D and/or experience in translational medicine strongly preferred
  • Deep expertise in immunology and immune-mediated/inflammatory diseases
  • Experience in rheumatology, gastrointestinal/mucosal inflammation, or dermatology
  • Proven track record of driving translational strategies that inform clinical development decisions
  • Demonstrated ability to lead highly matrixed teams
  • Strong analytical and problem-solving capabilities
  • Excellent communication skills
  • Working knowledge of biostatistics, bioinformatics, and advanced data analytics
  • Experience advancing precision medicine strategies
  • Must be a US or Puerto Rico resident
  • Visa sponsorship is not available
  • 10% travel required

Benefits

Comp & perks
  • Annual bonus
  • Long-term incentive, if applicable
  • Medical, dental, and vision healthcare
  • Other insurance benefits for employee and family
  • Retirement benefits, including 401(k)
  • Paid holidays
  • Vacation
  • Compassionate days
  • Sick days
  • Hybrid work arrangements
  • Domestic relocation