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About the role
Key responsibilities & impact- Design, conduct, analyse, interpret and report preclinical PK, PK/PD and TK studies in compliance with ethical and regulatory standards
- Evaluate ADME properties and pharmacokinetic characteristics of drug candidates, including small molecules, antibodies, antibody-drug conjugates and cell therapies
- Act as the DMPK subject matter expert in multidisciplinary drug discovery research projects
- Support research areas including immuno-oncology, antibody-drug conjugates, cancer genomics, pain and inflammatory diseases
- Design, monitor and oversee in vivo PK studies at external laboratories and CRO partners
- Prepare study protocols, reports, scientific documentation and DMPK contributions to regulatory submissions
- Collaborate with DMPK, pharmacology, bioanalytics and project teams to implement study plans, interpret data and contribute to project strategies
- Maintain and continuously develop DMPK research technologies, methodologies and data analysis approaches
- Contribute to digitalization and automation initiatives improving data flow and streamlining analysis
- Supervise and mentor research associates and provide scientific support in laboratory activities
Requirements
What you’ll need- PhD or PharmD in Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, Biomedical Sciences, Biochemistry, or another relevant discipline; alternatively, an MSc with a minimum of 4–5 years of relevant experience in pharmacokinetics, drug metabolism or pharmacology
- Authorization to design animal studies for scientific purposes
- Hands-on experience conducting in vivo studies
- Motivation to develop expertise in pharmacokinetics, drug metabolism, ADME, PK/PD relationships and translational pharmacology
- Ability to independently design, conduct, analyse and report in vivo PK, PK/PD and TK studies
- Experience preparing study protocols and reports
- Excellent scientific writing, documentation and presentation skills
- Ability to work effectively in multidisciplinary teams and communicate scientific information clearly in English
- Problem-solving ability, scientific curiosity, ability to manage priorities and proactive approach to developing innovative solutions
- Experience in pharmaceutical or biotechnology industry drug discovery and/or development is an advantage
- Experience with biologics, antibodies, ADCs or cell therapies is an advantage
- Understanding of regulatory requirements and industry standards related to preclinical drug development is an advantage
- Experience with pharmacokinetic modelling and simulation approaches is an advantage
- Experience working with CROs and managing outsourced studies is an advantage
- Experience implementing new technologies, digitalisation or automation solutions in DMPK research is an advantage
- Approved medical examination including drug testing required prior to employment
- Security clearance required prior to employment
Benefits
Comp & perks- A chance to contribute to cutting-edge research in a company with a highly promising R&D pipeline
- A supportive environment that values your strengths and encourages professional growth
- Career development opportunities tailored to your expertise and aspirations
- Collaborative workplace culture built on mutual respect, continuous learning, and trust
- Hybrid working opportunities in accordance with Orion Pharma's policy