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Praxis

Program Executive – Early Phase

Praxis

. Lead the integrated program strategy and development plan through early clinical development, proof-of-concept, and preparation for later-stage development .

Posted 10/15/2026full-timeRemote • United StatesMid-LevelSenior💰 $300,000 - $350,000 per yearWebsite

Core Competencies

Role fit
Core Competencies

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Demonstrates expertise in leading integrated program strategy and execution for early clinical development, with a strong focus on cross-functional collaboration and decision-making. Proven ability to manage complex development programs, including budget and resource planning, while ensuring alignment with regulatory and clinical strategies.

Highest-signal resume keywords
Program Strategy OwnershipCross-Functional LeadershipFDA Interaction ExperienceEnd-to-End Drug Development UnderstandingMatrix Team Leadership

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills
Clinical DevelopmentRegulatory StrategyResource PlanningBudget ManagementEvidence GenerationRisk EvaluationDecision-MakingBiomarker IntegrationTherapeutic Program LeadershipProof-of-Concept Development
Soft Skills
AccountabilityInfluencing Senior StakeholdersCollaborationTransparencyHigh Performance
Industry Keywords
Phase 1 DevelopmentPhase 2 DevelopmentCNS TherapiesRare Disease DevelopmentPatient StratificationBiotechnologyGovernance CommitteesHealth Authority InteractionsTranslational SciencesCompetitive Evidence

About the role

Key responsibilities & impact
  • Lead the integrated program strategy and development plan through early clinical development, proof-of-concept, and preparation for later-stage development
  • Drive cross-functional execution, governance, and decision-making against program objectives, timelines, and key scientific, clinical, and business milestones
  • Own program strategy, budget, resource planning, and investment recommendations, including acceleration, adaptation, and go/no-go decisions
  • Partner across Clinical Development, Research, Translational Sciences, Regulatory, Technical Operations, Medical, Biometrics, Finance, and other functions to build an integrated evidence-generation strategy
  • Evaluate emerging clinical, translational, regulatory, competitive, and operational data to identify risks, opportunities, and alternative development paths
  • Lead preparation for key health authority interactions and ensure alignment across clinical, regulatory, CMC, and evidence-generation strategies
  • Represent the program with executive leadership, governance committees, partners, and external stakeholders while fostering accountability, transparency, and high performance
  • Translate emerging data into decisive action and drive high-quality execution across a high-priority development program

Requirements

What you’ll need
  • Demonstrated experience leading or co-leading therapeutic programs through early clinical development and meaningful value-inflection points, including first-in-human, dose optimization, proof-of-mechanism, proof-of-concept, or transition to later-stage development
  • Proven cross-functional leadership with accountability for integrated program strategy and execution in Phase 1 and/or Phase 2 development
  • Direct ownership of program strategy, budgets, resource planning, governance, and investment recommendations for complex development programs
  • Experience integrating clinical, translational, biomarker, preclinical, regulatory, and competitive evidence to make sound decisions with incomplete or evolving data
  • Experience leading or preparing significant interactions with FDA and/or other global health authorities
  • Demonstrated ability to lead matrixed teams, resolve competing perspectives, and influence senior stakeholders without relying on formal authority
  • Strong understanding of end-to-end drug development and ability to connect near-term decisions to long-term product and patient impact
  • Preferred: Experience developing therapies in CNS
  • Preferred: Experience with rare disease development, biomarker-driven development, patient stratification, or innovative proof-of-concept strategies
  • Preferred: Alliance or partnership management experience
  • Preferred: Success operating in lean, fast-paced biotechnology organizations where leaders move fluidly between strategy and execution
  • Comfort with screen work, basic hand coordination, focus, regular computer/device/office equipment use, clear communication, and occasional movement

Benefits

Comp & perks
  • 99% of the premium paid for medical, dental and vision plans
  • Company-paid life insurance, AD&D, disability benefits, and voluntary plans
  • Dollar-for-dollar matching up to 6% on eligible 401(k) contributions
  • Long-term stock incentives and ESPP
  • Discretionary quarterly bonus
  • Extremely flexible wellness benefit
  • Generous PTO
  • Paid holidays
  • Company-wide shutdowns
  • Reasonable accommodations may be made to enable individuals with disabilities