Director, Clinical Operations

RhyGaze

. Lead the day-to-day management and oversight of clinical trials within the ophthalmology portfolio to ensure deliverables are met and within budget .

Posted 10/27/2026full-timeRemote • United StatesLeadWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive experience in clinical operations, particularly in managing clinical trials within the ophthalmology portfolio, ensuring compliance with protocols, GCP, and regulatory requirements. Proven ability to develop study documents, manage CROs, and lead cross-functional collaboration for successful program delivery.

Highest-signal resume keywords

Clinical Trial ManagementOphthalmology ExperienceGCP ComplianceCRO ManagementStudy Document Development

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical OperationsStudy Budget ManagementEnrollment ProjectionsOperational PlanningTrial Master File MaintenanceProtocol DevelopmentInformed Consent Form AuthoringClinical Study Report WritingSOP DevelopmentRisk Identification

Soft Skills

Interpersonal SkillsAnalytical SkillsProblem-Solving SkillsAdaptabilityTeam Collaboration

Industry Keywords

Clinical TrialsPhI–PhIIIGene TherapyStakeholder CommunicationGlobal Collaboration

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Lead the day-to-day management and oversight of clinical trials within the ophthalmology portfolio to ensure deliverables are met and within budget
Develop and maintain study timelines, enrollment projections, operational plans, and study budgets
Oversee and manage CROs and other external vendors
Contribute to or author study documents, including protocols, informed consent forms, investigator brochures, clinical study reports, and other documents and plans
Ensure the Trial Master File is set up and maintained appropriately throughout the trial, including periodic reviews
Ensure studies are executed in accordance with protocols, GCP, company SOPs, and applicable regulatory requirements
Provide operational input into clinical development plans and portfolio strategy discussions
Participate in developing clinical operations processes and SOPs
Establish and maintain collaboration with global cross-functional colleagues to ensure timely, high-quality, and within-budget program delivery
Keep stakeholders advised on project status and emerging issues
Identify emerging risks, issues, and opportunities across programs and translate insights into practical actions
Manage and develop clinical operations personnel as the program advances and the team expands

Requirements

What you’ll need

Minimum of 8-10 years of experience in clinical operations with significant clinical trial experience globally across PhI–PhIII
Ability to build strong relationships with the sites and CRO
Ability to deal with ambiguity and work in a dynamic, fast-paced environment and adapt to changes in program or project planning
Demonstrated self-starter and team player with strong interpersonal skills
Excellent written and verbal skills
Strong analytical and problem-solving skills, with strong attention to detail
Experience in ophthalmology and/or gene therapy preferred
Candidates need to be legally able to work in the US (US citizen or US work permit)

Benefits

Comp & perks

Opportunity to help develop breakthrough therapies for patients with serious vision-threatening diseases
Work alongside a passionate, highly experienced team at the forefront of ophthalmology innovation
Meaningful impact in a growing biotech company
Collaborative, entrepreneurial culture where science and innovation drive decision-making