Clinical Trial Manager II

Syneos Health

. Provide site management oversight, clinical monitoring and central monitoring deliverables, focusing on patient safety, protocol/GCP/regulatory compliance and data integrity .

Posted 11/4/2026full-timeRemote • Brazil, Argentina, Mexico, Chile, PeruMid-LevelSeniorWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical site management and monitoring, ensuring compliance with Good Clinical Practice and regulatory requirements while effectively leading teams to achieve project milestones. Proficient in risk management and problem-solving techniques to address complex issues in clinical research.

Highest-signal resume keywords

Clinical Site ManagementRisk-Based MonitoringGood Clinical PracticeBudget ManagementTeam Leadership

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical MonitoringProtocol ComplianceData IntegrityRisk AssessmentClinical Trial ManagementMonitoring DocumentationStudy Tools DevelopmentCTMS ConfigurationEDC SystemsUAT Oversight

Soft Skills

Communication SkillsConflict ResolutionCritical ThinkingInterpersonal SkillsPresentation Skills

Tools & Technologies

CTMSEDCEDiaryEPROTMFIVRS/IWRSDashboardsClinical Monitoring Plan

Industry Keywords

Clinical TrialsRegulatory ComplianceProtocol ExecutionPatient RecruitmentInternational Environment

About the role

Key responsibilities & impact

Provide site management oversight, clinical monitoring and central monitoring deliverables, focusing on patient safety, protocol/GCP/regulatory compliance and data integrity
Oversee site interactions from activation through closeout, including patient recruitment and investigator payments
Identify critical data, process and protocol-execution risks and develop risk mitigations
Review study scope of work, budget and protocol content; ensure clinical project teams understand contractual obligations and parameters
Identify and escalate risks affecting timelines, quality, budget or contracted scope
Participate in and present at key meetings, including Kick Off Meetings
Serve as an escalation point for investigator site staff and interact with principal investigators and other site staff by phone or in person
Collaborate with Study Start Up, Patient Recruitment, Data Management and other functional leaders to meet study milestones
Develop and maintain clinical study tools and templates, including the Clinical Monitoring Plan
Ensure CTMS, dashboards and other systems are configured and available, including overseeing UAT and access/audit trail reviews
Coordinate training for study teams on protocols, CRF completion, dashboards, SOPs, plans and timelines
Oversee CRA and Central Monitor resourcing, site assignments and team conduct
Ensure quality and visibility of clinical monitoring, central monitoring and site management deliverables using approved systems and tracking tools
Review project oversight dashboards and clinical trial systems including CTMS, EDC, eDiary, ePRO, TMF, IVRS/IWRS and central monitoring dashboards
Participate in development of study risk assessment plans and ensure assigned team members comply with monitoring strategies and risk plans
Review the quality and content of monitoring documentation and ensure timely delivery according to company and sponsor specifications
Interact with clients, project management, leadership and functional departments; provide status updates and solutions for protocol-execution and site-management obstacles
Support inspection readiness for clinical trial management scope
Oversee CRAs and Central Monitors, assess process/training/CMP compliance, identify emerging risks and support corrective action plans
Support activities to achieve data cut and lock deadlines
Provide performance feedback to line managers on staff strengths and development areas
May be assigned to larger, more complex trials

Requirements

What you’ll need

Bachelor’s degree or RN in a related field or equivalent combination of education, training and experience
Demonstrated ability to lead and align teams in the achievement of project milestones
Demonstrated capability of working in an international environment
Demonstrated expertise in site management and monitoring (clinical or central)
Preferred experience with risk-based monitoring
Understanding of clinical trial management financial principles and budget management
Knowledge of Good Clinical Practice/ICH Guidelines and other applicable regulatory requirements
Good computer skills
Good communication, presentation and interpersonal skills among project team and with sites
Strong conflict resolution skills
Ability to apply problem-solving techniques to resolve complex issues and apply a risk-management approach to identifying and mitigating potential threats to successful clinical research projects
Critical-thinking ability to determine causes and appropriate solutions when identifying issues
Moderate travel may be required, approximately 20%

Benefits

Comp & perks

Career development and progression
Supportive and engaged line management
Technical and therapeutic area training
Peer recognition
Total rewards program
Inclusive culture where employees can authentically be themselves
Reasonable accommodations, when appropriate, under the Americans with Disabilities Act