Clinical Trial Manager II

Syneos Health

. Provide site management oversight, clinical monitoring and central monitoring deliverables, focusing on patient safety, protocol/GCP/regulatory compliance and data integrity .

Posted 11/9/2026full-timeRemote • North Carolina • United StatesMid-LevelSeniorWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical monitoring and site management, ensuring compliance with Good Clinical Practice and regulatory requirements while effectively leading teams to achieve project milestones. Proficient in risk management and problem-solving techniques to maintain data integrity and patient safety throughout clinical trials.

Highest-signal resume keywords

Clinical MonitoringSite ManagementRisk-Based MonitoringGood Clinical PracticeBudget Management

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Trial ManagementData IntegrityProtocol ComplianceRisk ManagementCritical Thinking

Soft Skills

Communication SkillsConflict ResolutionInterpersonal SkillsPresentation SkillsTeam Leadership

Tools & Technologies

CTMSEDCEDiaryEPROTMFIVRS/IWRS

Industry Keywords

Good Clinical PracticeICH GuidelinesClinical Monitoring PlanPatient SafetyRegulatory Compliance

About the role

Key responsibilities & impact

Provide site management oversight, clinical monitoring and central monitoring deliverables, focusing on patient safety, protocol/GCP/regulatory compliance and data integrity
Oversee site interactions from activation through closeout, including recruitment and investigator payments
Identify critical data, process and protocol execution risks and develop mitigations
Review study scope, budget and protocol content; communicate contractual obligations to CRAs and Central Monitors
Identify and escalate risks to timelines, quality, budget and contracted scope
Participate in and present at key meetings, including Kick Off Meetings
Serve as an escalation point for investigator site staff and interact with principal investigators and site staff by phone or in person
Coordinate with Study Start Up, Patient Recruitment and Data Management to achieve study milestones
Develop and maintain clinical study tools and templates, including the Clinical Monitoring Plan
Ensure CTMS, dashboards and other systems are configured, available and subject to required UAT and audit-trail reviews
Coordinate study-team training on protocols, CRF completion, dashboards, SOPs, plans and timelines
Oversee CRA and Central Monitor resourcing, site assignments, conduct, compliance and delivery risks
Ensure quality and visibility of clinical monitoring, central monitoring and site management deliverables
Review CTMS, EDC, eDiary, ePRO, TMF, IVRS/IWRS and central monitoring dashboards to oversee site and patient activities
Oversee compliance with monitoring strategies, CMP/SMP and risk plans
Review site and central monitoring documentation for quality, compliance, patient safety, trial conduct and data integrity
Interact with clients, project management, leadership and functional departments; provide status updates and solutions
Support inspection readiness for clinical trial management
Oversee CRAs and Central Monitors, assess compliance and emerging risks, and support corrective action plans
Support activities to achieve data-cut and database-lock deadlines
Provide staff-performance feedback to line managers
May be assigned to larger, more complex trials

Requirements

What you’ll need

Bachelor’s degree or RN in a related field or equivalent combination of education, training and experience
Demonstrated ability to lead and align teams in the achievement of project milestones
Demonstrated capability of working in an international environment
Demonstrated expertise in site management and monitoring (clinical or central)
Preferred experience with risk-based monitoring
Understanding of clinical trial management financial principles and budget management
Knowledge of Good Clinical Practice/ICH Guidelines and other applicable regulatory requirements
Good computer skills
Good communication, presentation and interpersonal skills among project team and with sites
Strong conflict resolution skills
Ability to apply problem-solving techniques to resolve complex issues and use a risk-management approach to identify and mitigate threats to successful clinical research projects
Critical thinking to determine causes and appropriate solutions when identifying issues
Moderate travel may be required, approximately 20%

Benefits

Comp & perks

Career development and progression
Supportive and engaged line management
Technical and therapeutic area training
Peer recognition and total rewards program
Total Self culture
Company car or car allowance
Medical, Dental and Vision health benefits
Company match 401k
Eligibility to earn commissions/bonus based on company and individual performance
Flexible paid time off (PTO)
Sick time