Global Clinical Trial Manager II

Syneos Health

. Provide site management oversight, clinical monitoring and central monitoring deliverables, focusing on patient safety, protocol/GCP/regulatory compliance and data integrity .

Posted 10/14/2026full-timeRemote • BulgariaSeniorWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in site management and clinical monitoring, ensuring compliance with Good Clinical Practice, ICH Guidelines, and regulatory requirements. Proficient in risk management, budget oversight, and effective communication within international clinical trial environments.

Highest-signal resume keywords

Site ManagementClinical MonitoringRisk-Based MonitoringGood Clinical PracticeBudget Management

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Trial ManagementData IntegrityProtocol ComplianceRisk ManagementClinical Monitoring PlansCTMSEDCEDiaryIVRS/IWRSSOPs

Soft Skills

Communication SkillsPresentation SkillsInterpersonal SkillsConflict ResolutionCritical Thinking

Tools & Technologies

CTMSEDCEDiaryEPROTMF

Industry Keywords

Good Clinical PracticeICH GuidelinesRegulatory ComplianceClinical TrialsPatient Safety

About the role

Key responsibilities & impact

Provide site management oversight, clinical monitoring and central monitoring deliverables, focusing on patient safety, protocol/GCP/regulatory compliance and data integrity
Oversee site interactions from activation through closeout, including recruitment and investigator payments
Identify critical data, process and protocol execution risks and develop mitigations
Review study scope, budget and protocol content; ensure the clinical project team understands contractual obligations
Identify and escalate risks to timelines, quality, budget and contracted scope
Participate in and present at key meetings, including Kick Off Meetings
Serve as an escalation point for investigator site communications and support site visits as needed
Coordinate handoffs with Study Start Up, Patient Recruitment and Data Management to meet study milestones
Develop and maintain clinical study tools and templates, including Clinical Monitoring Plans
Ensure CTMS, dashboards and related systems are configured, tested and maintained
Coordinate study-team training on protocols, CRFs, dashboards, SOPs, plans and timelines
Oversee CRA and Central Monitor resourcing, assignments, conduct and delivery risks
Ensure quality and visibility of clinical monitoring, central monitoring and site management deliverables
Review oversight dashboards and clinical trial systems including CTMS, EDC, eDiary, ePRO, TMF and IVRS/IWRS
Ensure team compliance with monitoring strategies, CMP/SMP and risk plans
Review site and central monitoring documentation and ensure timely revisions, approvals and delivery
Provide client, project management and leadership status updates, risks and solutions
Support compliance with protocol, SOPs, ICH GCP and country regulations, including inspection readiness
Oversee CRAs and Central Monitors, assess compliance and support corrective action plans
Support activities to achieve data cut and database lock deadlines
Provide staff performance feedback to line managers
May be assigned to larger, more complex trials

Requirements

What you’ll need

Bachelor’s degree or RN in a related field or equivalent combination of education, training and experience
Demonstrated ability to lead and align teams in the achievement of project milestones
Demonstrated capability of working in an international environment
Demonstrated expertise in site management and monitoring (clinical or central)
Preferred experience with risk-based monitoring
Understanding of clinical trial management financial principles and budget management
Knowledge of Good Clinical Practice/ICH Guidelines and other applicable regulatory requirements
Good computer skills
Good communication, presentation and interpersonal skills
Strong conflict resolution skills
Ability to apply problem solving techniques to resolve complex issues and apply a risk management approach
Critical thinking to determine causes and appropriate solutions
Moderate travel may be required, approximately 20%

Benefits

Comp & perks

Career development and progression
Supportive and engaged line management
Technical and therapeutic area training
Peer recognition
Total rewards program
Inclusive culture
Reasonable accommodations when appropriate