Principal Site Activation Manager

Syneos Health

. Lead and oversee global site activation activities from study start-up through site readiness .

Posted 10/22/2026full-timeMorrisville • North Carolina • United StatesLead💰 $97,300 - $170,300 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in leading global site activation activities, managing timelines, risks, and deliverables while ensuring compliance with regulatory requirements and sponsor expectations. Proven ability to collaborate with cross-functional teams and provide guidance to Site Activation Managers and study teams.

Highest-signal resume keywords

Global Site Activation LeadershipRegulatory Compliance ManagementTimeline and Risk ManagementCross-Functional CollaborationIssue Resolution Support

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Site Activation Strategy DevelopmentPerformance Metrics TrackingStudy Start-Up ManagementDeliverable ManagementSOP Compliance

Soft Skills

Guidance and OversightProblem-SolvingStakeholder Engagement

Industry Keywords

Clinical OperationsRegulatory AffairsContracts and BudgetsStudy TeamsActivation Milestones

About the role

Key responsibilities & impact

Lead and oversee global site activation activities from study start-up through site readiness
Develop and execute country and site activation strategies
Manage timelines, risks, and deliverables across multiple studies or programs
Partner closely with Clinical Operations, Regulatory Affairs, Contracts & Budgets, and external stakeholders
Drive performance metrics and ensure activation milestones are achieved
Provide guidance and oversight to Site Activation Managers and study teams
Support issue escalation and resolution for complex start-up challenges
Ensure compliance with regulatory requirements, SOPs, and sponsor expectations

Requirements

What you’ll need

Equivalent experience, skills, and/or education will also be considered
Compliance with regulatory requirements, SOPs, and sponsor expectations
Ability to manage timelines, risks, and deliverables across multiple studies or programs
Ability to partner with Clinical Operations, Regulatory Affairs, Contracts & Budgets, and external stakeholders
Ability to provide guidance and oversight to Site Activation Managers and study teams
Ability to support issue escalation and resolution for complex start-up challenges

Benefits

Comp & perks

Career development and progression
Supportive and engaged line management
Technical and therapeutic area training
Peer recognition and total rewards program
Inclusive culture
Company car or car allowance
Medical, Dental and Vision health benefits
Company match 401k
Eligibility to participate in Employee Stock Purchase Plan
Eligibility to earn commissions/bonus based on company and individual performance
Flexible paid time off (PTO)
Sick time