Senior Clinical Trial Manager

Syneos Health

. Provide site management oversight, clinical monitoring, and central monitoring deliverables .

Posted 10/6/2026full-timeMelbourne • AustraliaSeniorWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical site management and monitoring, ensuring compliance with Good Clinical Practice and regulatory requirements while effectively leading teams to achieve project milestones. Proficient in risk management and problem-solving techniques to maintain data integrity and patient safety throughout the clinical trial process.

Highest-signal resume keywords

Clinical Site ManagementGood Clinical Practice ComplianceRisk-Based MonitoringBudget ManagementTeam Leadership

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical MonitoringProtocol ReviewData IntegrityRisk AssessmentClinical Trial ManagementStudy Start Up CoordinationClinical Monitoring Plans DevelopmentUAT OversightAudit Trail ReviewConflict Resolution

Soft Skills

Critical ThinkingProblem-SolvingTeam AlignmentCommunicationCoaching

Tools & Technologies

CTMSEDCEDiaryEPROsTMFIVRS/IWRSDashboards

Industry Keywords

Clinical TrialsRegulatory ComplianceInternational EnvironmentPatient SafetyInvestigator Payments

About the role

Key responsibilities & impact

Provide site management oversight, clinical monitoring, and central monitoring deliverables
Focus on patient safety, protocol/GCP/regulatory compliance, and data integrity
Oversee site interactions from activation through closeout, including recruitment and investigator payments where applicable
Review study scope, budget, protocol content, contractual obligations, and clinical project team awareness
Identify, escalate, and mitigate risks affecting timelines, quality, budget, and protocol execution
Participate in and present at key meetings, including Kick Off Meetings
Serve as an escalation point for investigator site staff and principal investigators
Coordinate with Study Start Up, Patient Recruitment, Data Management, and other functional leaders
Develop and maintain clinical study tools and templates, including Clinical Monitoring Plans
Ensure CTMS, dashboards, and other systems are configured and available; oversee UAT and audit trail reviews
Coordinate study-team training on protocols, CRFs, dashboards, SOPs, plans, guidelines, data plans, and timelines
Oversee CRA and Central Monitor resourcing, assignments, conduct, compliance, and delivery quality
Review oversight dashboards and clinical trial systems including CTMS, EDC, eDiary, ePROs, TMF, IVRS/IWRS, and central monitoring dashboards
Oversee monitoring strategy compliance and participate in risk assessment planning
Review site and central monitoring documentation and ensure timely revisions, approvals, and delivery
Provide status updates and solutions to clients, project management, and leadership
Support inspection readiness for clinical trial management
Oversee CRAs and Central Monitors, develop and support corrective action plans, and support data cut and lock deadlines
Provide staff performance feedback to line managers
Coordinate clinical activities across portfolios and coach or mentor CTMs when assigned

Requirements

What you’ll need

Bachelor’s degree or RN in a related field or equivalent combination of education, training, and experience
Demonstrated ability to lead and align teams in the achievement of project milestones
Demonstrated capability of working in an international environment
Demonstrated expertise in site management and monitoring (clinical or central)
Preferred experience with risk-based monitoring
Understanding of clinical trial management financial principles and budget management
Knowledge of Good Clinical Practice/ICH Guidelines and other applicable regulatory requirements
Good computer skills
Strong conflict resolution skills
Ability to apply problem-solving techniques to resolve complex issues and apply a risk management approach
Critical thinking to determine causes and appropriate solutions when identifying issues
Moderate travel capability, approximately 20%

Benefits

Comp & perks

Career development and progression
Supportive and engaged line management
Technical and therapeutic area training
Peer recognition
Total rewards program
Total Self culture supporting authenticity and inclusion
Diversity, belonging, and inclusive workplace culture