Director, Global Drug Substance Commercialization, Conjugation

Vaxcyte

. Lead and facilitate launch readiness and commercial supply of glycoconjugate drug substances, including polysaccharide activation, conjugation, and associated raw materials .

Posted 9/17/2026full-timeRemote • California • United StatesLead💰 $210,000 - $245,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive expertise in glycoconjugate drug substance production, including polysaccharide activation and conjugation processes, while providing strategic leadership and effective communication across diverse teams and stakeholders.

Highest-signal resume keywords

Glycoconjugate Vaccine ExperiencePolysaccharide ActivationConjugation to Carrier ProteinsLeadership in MSATRegulatory Filings Review

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Conjugate Production ProcessesProcess ValidationData AnalyticsTechnical TransferLifecycle ManagementProcess OptimizationScientific LeadershipRegulatory ComplianceManufacturing Process ImprovementFacility Readiness

Soft Skills

Excellent CommunicationProblem SolvingStrategic PlanningCollaborationOrganizational Skills

Industry Keywords

Chemical EngineeringBiochemical EngineeringBiochemistryManufacturing OperationsCMO CollaborationHealth Authority InteractionDiverse Background InteractionEntrepreneurial ApproachMatrixed Team LeadershipProcess Development

About the role

Key responsibilities & impact

Lead and facilitate launch readiness and commercial supply of glycoconjugate drug substances, including polysaccharide activation, conjugation, and associated raw materials
Lead technical launch planning and execution for regulatory filings, facility readiness, and launch supplies
Ensure effective communication of scientific and commercial rationale for critical raw material manufacturing processes to internal stakeholders, CMOs, and regulatory agencies
Plan and execute commercial lifecycle management activities
Provide strategic and scientific leadership for polysaccharide activation and conjugation processes
Build and develop a highly skilled global conjugation manufacturing team and support staffing recommendations
Continuously improve process understanding and robustness by monitoring, trending, and optimizing operations
Collaborate with Regulatory, CMC, Quality, Supply Chain, Procurement, and Process Engineering teams
Support technical transfers and integration of new technologies
Support internal and external manufacturing networks, materials management, and data analytics
Lead process validation and comparability activities
Review and author regulatory filings and respond to health authority questions
Communicate process performance to internal and external stakeholders
Serve as DS Commercialization lead for Conjugation within Global Manufacturing Operations

Requirements

What you’ll need

Degree(s) in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related discipline with a minimum of 10+ years of relevant experience for Ph.D., 12+ years for M.S./M.A., or 16+ years for B.S./B.A.
Extensive experience in conjugate production processes, including polysaccharide activation, conjugation to carrier proteins, and associated purification processes across multiple operational scales
Experience with glycoconjugate vaccines is highly preferred
Leadership experience in MSAT or Process Development in supervisory and/or matrixed team roles
Deep technical knowledge applied collaboratively to establish strategic plans and achieve collective goals
Excellent organization, problem solving and strategic planning skills
Highly skilled in verbal and written communication
Ability to interact effectively with people of diverse backgrounds and perspectives
Ability to recognize needs and challenges and implement effective solutions
Ability to seek and analyze data from various sources to support decisions and align others with organizational strategy
Entrepreneurial and creative approach to developing innovative ideas
10–30% travel required

Benefits

Comp & perks

Comprehensive benefits
Equity component
Remote work arrangement