Senior Scientist II, Recombinant Peptide Process Development

AbbVie

. Lead recombinant peptide process-development activities, including expression strategy, host and clone screening, process optimization, and scale-up .

Posted 11/4/2026full-timeRemote • California • United StatesSenior💰 $109,500 - $208,500 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in recombinant peptide process development, including expression strategy, optimization, and purification techniques. Proficient in microbial physiology, experimental design, and data interpretation, with strong communication and mentoring abilities.

Highest-signal resume keywords

Recombinant Peptide Process DevelopmentMicrobial PhysiologyExpression Process OptimizationPeptide Purification TechniquesData Interpretation and Troubleshooting

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Peptide Recovery ProcessesClone ScreeningFermentationPreparative ChromatographyHPLCUPLCLC-MSFusion-Partner Cleavage StrategiesAI/ML ApproachesExperimental Design

Soft Skills

Scientific WritingOral CommunicationMentoringProject ManagementCollaboration

Tools & Technologies

BioreactorsMicroscale CultivationParallel BioreactorsHigh-Throughput Approaches

Industry Keywords

Recombinant Expression SystemsE. ColiYeastFusion-Tag StrategiesProcess OptimizationQuality ComplianceScientific PublicationsConference Presentations

About the role

Key responsibilities & impact

Lead recombinant peptide process-development activities, including expression strategy, host and clone screening, process optimization, and scale-up
Design and evaluate expression constructs and microbial hosts, including Escherichia coli and yeast
Develop and assess fusion-tag and carrier-protein strategies, including His-tag, GST, SUMO, and inclusion-body expression
Design and conduct clone-screening studies using microscale cultivation, parallel bioreactors, and other scale-down or high-throughput approaches
Develop and optimize peptide recovery processes, including cell harvest and lysis, inclusion-body isolation and processing, and chemical or enzymatic cleavage of fusion partners
Troubleshoot aggregation, low solubility, degradation, incomplete cleavage, and co-eluting impurities
Interpret HPLC, UPLC, and LC-MS data to assess peptide identity, mass accuracy, purity, and process-related impurities
Evaluate emerging technologies and process approaches, including genetic code expansion when relevant
Apply AI/ML approaches to analyze peptide sequence, structure, and experimental data
Communicate scientific plans, progress, challenges, conclusions, and recommendations to project teams and stakeholders
Mentor junior scientists and provide technical direction in recombinant peptide bioprocessing
Contribute to scientific publications and conference presentations
Manage priorities and timelines while following corporate standards for safety, quality, and compliance

Requirements

What you’ll need

PhD with typically 4+ years of relevant experience, master’s degree or equivalent education with 10+ years of relevant experience, or bachelor’s degree or equivalent education with typically 12+ years of relevant experience
Thorough theoretical and practical understanding of relevant scientific disciplines
Hands-on experience in microbial physiology and recombinant expression systems, particularly E. coli and/or yeast
Ability to independently design, execute, and interpret critical experiments
Experience developing or optimizing expression processes for peptides, small proteins, or other products susceptible to degradation or instability
Experience with strain or clone screening, fermentation, and process optimization
Familiarity with bioreactors and scale-down or parallel cultivation approaches
Experience with preparative chromatography and peptide or protein purification
Experience with peptide recovery and fusion-partner cleavage strategies
Strong experimental design, data interpretation, troubleshooting, scientific writing, and oral communication skills
Ability to manage multiple priorities and timelines and work effectively in a matrixed, cross-functional environment

Benefits

Comp & perks

Paid time off, including vacation, holidays, and sick leave
Medical, dental, and vision insurance
401(k)
Eligibility to participate in long-term incentive programs