Director, Epidemiology – Methodological Innovation

Ambry Genetics

. Lead development of novel real-world evidence approaches, including external control arms, causal inference in high-dimensional data, and integration of longitudinal clinical data with molecular/genomic signatures .

Posted 10/2/2026full-timeRemote • California • United StatesLead💰 $170,000 - $230,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in real-world evidence methodologies, including causal inference and integration of clinical data with genomic signatures, while ensuring compliance with regulatory standards. Proven leadership in guiding cross-functional teams and mentoring junior scientists in high-impact research environments.

Highest-signal resume keywords

PhD Or PharmD In Epidemiology7+ Years In HEOR/RWEDeep Expertise In OncologyAdvanced Skills In R Or SASExperience With Real-World Data

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Causal InferenceTarget Trial EmulationPropensity Score ApplicationsMachine Learning-Augmented EpidemiologyRetrospective Database AnalysesStudy Protocol ArchitectureLongitudinal Clinical Data IntegrationNovel Methodologies DevelopmentHigh-Impact PublicationsData Science Integration

Soft Skills

Exceptional CommunicationMentoring Junior ScientistsSimplifying Complex MethodologiesLeadership In Cross-Functional TeamsStrategic Roadmap Development

Industry Keywords

Real-World EvidenceBiopharmaRegulatory StandardsGEPHIPAAHealth EconomicsBiostatisticsOncologyEHRClaims Data

About the role

Key responsibilities & impact

Lead development of novel real-world evidence approaches, including external control arms, causal inference in high-dimensional data, and integration of longitudinal clinical data with molecular/genomic signatures
Oversee end-to-end retrospective database analyses and architect study protocols
Serve as a subject matter expert for biopharma clients and advise on first-in-kind study designs
Contribute to high-impact publications and presentations at ISPOR, ISPE, and ASCO
Partner with Key Account Directors and Business Development to identify opportunities for novel methodologies
Bridge Data Science, Biostatistics, and Product teams to productize scalable methods
Ensure innovative research meets regulatory and ethical standards, including GEP and HIPAA, and deliver high-quality results on schedule

Requirements

What you’ll need

PhD (preferred) or PharmD in Epidemiology, Biostatistics, Health Economics, or a related quantitative field
7+ years in HEOR/RWE
At least 3 years in a leadership capacity
Deep expertise in oncology
Proven track record of developing or implementing advanced methods, such as target trial emulation, propensity score applications in complex cohorts, or machine learning-augmented epidemiology
Advanced skills in R or SAS
Experience with real-world data, including EHR, claims, and/or genomic data
Exceptional ability to simplify complex methodological hurdles into a clear strategic roadmap for biopharma executives
Demonstrated experience mentoring junior scientists and leading cross-functional squads in a fast-paced, high-growth environment

Benefits

Comp & perks

Incentive compensation may be offered
Restricted stock units may be offered
Medical and other benefits depending on the position
Equal opportunity employer