Clinical Variant Scientist I

ARUP Laboratories

. Interpret and classify genetic variants identified through clinical testing .

Posted 10/14/2026full-timeRemote • United StatesMid-LevelSenior💰 $79,602 - $119,434 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in genetic variant interpretation and clinical report writing, with a strong understanding of next-generation sequencing and genomic data analysis. Proficient in maintaining compliance with regulatory standards and collaborating effectively with multidisciplinary teams.

Highest-signal resume keywords

Genetic Variant InterpretationNext-Generation Sequencing AnalysisClinical Report WritingRegulatory ComplianceData Quality Evaluation

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Genomic Data AnalysisMolecular GeneticsVariant ClassificationBioinformatics ProcessesClinical Laboratory Data EvaluationScientific Literature ReviewData Entry AccuracyGenetic Mechanisms of DiseaseACMG Guidelines FamiliarityNGS/MPS Experience

Soft Skills

Strong Communication SkillsInterpersonal SkillsProblem-Solving AbilityCollaboration SkillsAttention to Detail

Tools & Technologies

Computational Prediction SoftwareOnline Human Genomic DatabasesGenomic Annotation ToolsLaboratory Information Management SystemsPersonal Protective Equipment

Industry Keywords

Clinical TestingSomatic Variant InterpretationCancer BiologyHeritable DisordersQuality AssuranceStandard Operating ProceduresClinical Care ImpactRegulatory StandardsCDC RegulationsOSHA Regulations

About the role

Key responsibilities & impact

Interpret and classify genetic variants identified through clinical testing
Review genomic data from oncology NGS tests and perform somatic variant interpretation
Evaluate data quality from next-generation sequencing/massively parallel sequencing platforms
Research clinical significance using medical literature, external databases, and computational prediction software
Collect and integrate data related to cancer biology and/or heritable disorders and potential clinical-care impact
Assess plausibility of laboratory results using patient demographics and clinical symptoms
Draft accurate and consistent clinical reports for medical director review
Collaborate with laboratory teams, genetic counselors, medical directors, scientists, staff, directors, and management
Troubleshoot unique scenarios and optimize clinical workflows and processes
Contribute to quality assurance, standard operating procedures, and best practices for variant interpretation
Maintain compliance with regulatory standards, policies, procedures, and record keeping
Accept, resolve, and assist with resolution of problems
Perform peer assessments as a Qualified Observer after two years of experience
Maintain current knowledge of genomic research and guidelines
Spend approximately 85–95% of time analyzing clinical cases

Requirements

What you’ll need

Master's degree or better in Biological Sciences or related field required
Ph.D. in genetics, molecular biology, or related biological science OR Master's degree in genetic counseling, genetics, molecular biology, or related biological science and 4 years of relevant clinical work experience
Relevant clinical work experience including writing, reading, and proofreading molecular genetics clinical reports
Experience critically reviewing scientific and/or medical literature
Experience with germline and/or somatic variant interpretation based on professional guidelines such as ACMG, AMP, and ClinGen preferred
Experience reviewing and analyzing NGS/MPS and/or genomic microarray data preferred
Experience utilizing online human genomic databases and genomic annotation preferred
Familiarity with NGS/MPS laboratory and bioinformatics processes preferred
In-depth knowledge of genetic mechanisms of disease relevant to somatic and/or germline variation preferred
Strong written, verbal, and interpersonal communication skills preferred
Ability to use standard nomenclature and professional standard classification guidelines
Ability to evaluate clinical laboratory data quality
Understanding of protein structure and function, RNA splicing, gene regulation, genetic mechanisms of disease, and sequence variants
Understanding of experimental methods, data analysis methods, and inferences for single-gene and high-throughput analyses
Ability to perform highly accurate data entry, recognize inconsistencies, and initiate resolution
Ability to correlate laboratory results with patient demographics and clinical symptoms
Ability to comply with regulatory policies, procedures, and record-keeping requirements
Ability to use personal protective equipment in a biohazard laboratory environment in accordance with CDC and OSHA regulations
Must be able to communicate effectively and perform fine motor, typing, visual, color vision, stooping, reaching, and sedentary work activities

Benefits

Comp & perks

Fully remote position
Professional growth and continuous development
Diversity-focused work environment
Flexible schedule determined by operational needs
Monday–Friday schedule, 40 hours per week
Occasional weekends may be included to meet clinical reporting requirements