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Core Competencies
Role fitCore Competencies
Use this summary to align your resume positioning with the role.
Demonstrates expertise in leading research projects in drug discovery, particularly in the design and development of PROTACs and degrader-antibody conjugates. Possesses strong analytical skills for evaluating SAR datasets and a deep understanding of pharmacokinetics and in vivo pharmacology.
Highest-signal resume keywords
Leading Research ProjectsSynthetic ChemistryMedicinal ChemistryStructure-Based DesignPhD in Organic Chemistry
ATS Keywords
Tailor your resumeApplicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills
PROTAC DesignDegrader-Antibody ConjugatesSAR GenerationMulti-Parametric OptimizationPharmacokinetic PrinciplesIn Vivo PharmacologyData AnalysisComputational Chemistry
Soft Skills
CollaborationCommunicationProblem SolvingStrategic Decision-Making
Tools & Technologies
Computational Chemistry ResourcesCRO Interaction
Industry Keywords
PharmaBiotechDrug DiscoveryAntibody-Drug Conjugates
About the role
Key responsibilities & impact- Lead chemistry efforts as part of a cross-functional project team to drive programs to key decisions across the preclinical pipeline
- Lead assigned PROTAC projects, potentially focused on degrader-antibody conjugates, from inception to clinical candidate nomination
- Design PROTACs, degrader-antibody conjugates, and libraries using computational chemistry resources
- Analyze complex, multivariate SAR datasets to generate testable hypotheses
- Interact with external CRO resources to fulfill synthetic and data needs according to timelines and standards
- Solicit and analyze experimentation and data to identify and prioritize issues and support decision-making
- Collaborate with functions across drug discovery
- Provide scientific updates to the manager and company executives
- Represent company interests at conferences and with external scientific organizations as needed
- Develop and communicate data-based strategic recommendations and decisions to research and development leadership
Requirements
What you’ll need- Proven track record of leading research projects through milestone decisions toward clinical candidate nomination
- Extensive experience in the synthetic and medicinal chemistry of antibody-drug conjugates
- Specific experience with degrader-antibody conjugates preferred
- Extensive knowledge of structure-based design, SAR generation, and multi-parametric optimization
- Deep understanding of pharmacokinetic principles and in vivo pharmacology
- Proven ability to collaborate and communicate project needs and strategy to multidisciplinary team members and senior leaders
- Must be legally authorized to work in the US without the need for employer sponsorship now or at any time in the future
- Must be able to lift/carry 15/30 pounds unassisted/assisted, with or without accommodation
- Must be able to work in a controlled environment with and around biological, infectious and hazardous materials
- Must be able to gown/degown PPE
- Must be able to use a computer and communicate via phone, video, and electronic messaging
- Must be able to engage in problem solving, analysis and dialogue and collaborate with others
- Must maintain general availability during standard business hours
- PhD in organic chemistry or medicinal chemistry
- 8+ years of pharma/biotech-based drug discovery experience
Benefits
Comp & perks- Competitive package of base and incentive compensation
- Comprehensive benefits program
- Group medical coverage
- Vision coverage
- Dental coverage
- Group and supplemental life insurance