Arvinas

General

• Lead chemistry efforts as part of a cross-functional project team to drive programs to key decisions across the preclinical pipeline
• Lead assigned PROTAC projects, potentially focused on degrader-antibody conjugates, from inception to clinical candidate nomination
• Design PROTACs, degrader-antibody conjugates, and libraries using computational chemistry resources
• Analyze complex, multivariate SAR datasets to generate testable hypotheses
• Interact with external CRO resources to fulfill synthetic and data needs according to timelines and standards
• Solicit and analyze experimentation and data to identify and prioritize issues and support decision-making
• Collaborate with functions across drug discovery
• Provide scientific updates to the manager and company executives
• Represent company interests at conferences and with external scientific organizations as needed
• Develop and communicate data-based strategic recommendations and decisions to research and development leadership

Medicinal Chemistry Project Leader