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Associate Director, Translational Medicine Lead
AstraZeneca. Own and execute end-to-end translational strategies for B-cell malignancy programs from preclinical through Phase 1/2 and, as needed, Phase 3 .
Core Competencies
Role fitCore Competencies
Use this summary to align your resume positioning with the role.
Demonstrates expertise in B-cell malignancy biology and translational strategies, with a strong focus on biomarker technologies and early-phase oncology clinical trials. Proven ability to lead cross-functional teams and integrate scientific data for informed decision-making.
Highest-signal resume keywords
PhD In Biological ScienceExperience With T-Cell Engaging BispecificsExpertise In Biomarker TechnologiesKnowledge Of B-Cell Malignancy BiologyUnderstanding Of Clinical Development Process
ATS Keywords
Tailor your resumeApplicant Tracking System Keywords
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Hard Skills
Biomarker Plan DevelopmentProtocol InputSample AnalysisFlow CytometryImmunohistochemistryMolecular ProfilingNGSCtDNACytokine ProfilingMRD Assessment
Soft Skills
Excellent CommunicationPresentation SkillsScientific LeadershipAbility To Work IndependentlyAbility To Operate Effectively In Teams
Tools & Technologies
Fit-For-Purpose AssaysCross-Functional Team CollaborationRegulatory Expectations For Biomarker ValidationCDx Development
Industry Keywords
Hematology-OncologyImmunologyOncologyMolecular BiologyB-ALLB-CLLNHLTherapeutic ResistanceTumor MicroenvironmentSmall-Molecule Hematology Therapeutics
Tech Stack
Tools & technologiesGo
About the role
Key responsibilities & impact- Own and execute end-to-end translational strategies for B-cell malignancy programs from preclinical through Phase 1/2 and, as needed, Phase 3
- Define indications, stratify patients, and refine target populations using human genetics, expression, and clinical data
- Design and interpret target-engagement and pharmacodynamic biomarker readouts for dose selection and proof of mechanism
- Investigate resistance mechanisms using longitudinal and relapse samples
- Analyze B-cell tumor biology, pathway interactions, and tumor microenvironment features to guide combinations
- Lead development, validation, and deployment of fit-for-purpose assays internally and with external laboratories/CROs
- Embed biomarker strategies and endpoints into protocols, sample manuals, and statistical plans
- Partner with biosamples and precision diagnostics teams on collection, traceability, and CDx alignment
- Represent Translational Medicine on cross-functional teams and connect insights across the B-cell portfolio
- Contribute to governance materials, study reports, Go/No-Go recommendations, health authority interactions, and filings
- Present scientific narratives internally and in external forums
Requirements
What you’ll need- PhD in a relevant biological science, including hematology-oncology, immunology, oncology, molecular biology, or related field
- Postdoctoral and/or industry experience required
- 0–3+ years of experience with T-cell engaging bispecifics in an oncology/hematology development context
- Demonstrated experience with antibody-drug conjugates in a hematology or oncology development context
- Experience contributing to early-phase oncology clinical trials, including biomarker plan development, protocol input, and sample analysis
- Expertise in biomarker technologies including flow cytometry, immunohistochemistry, molecular profiling, NGS, ctDNA, MRD assessment, cytokine/immune profiling, and other omics-based approaches
- Knowledge of B-cell malignancy biology spanning B-ALL, B-CLL, and NHL, including disease pathogenesis, standard-of-care landscape, and therapeutic resistance
- In-depth understanding of immunology and the tumor microenvironment in B-cell cancers
- Understanding of the end-to-end clinical development process from dose escalation through registration
- Ability to work independently and deliver translational programs with regular managerial support
- Ability to operate effectively and demonstrate scientific leadership within cross-functional teams in a matrixed pharma or biotech environment
- Ability to integrate scientific data and articulate implications for Go/No-Go decisions
- Excellent communication and presentation skills
- Desired: experience with small-molecule hematology therapeutics, cell therapy programs, MRD methodologies, multi-omic biomarker data, regulatory expectations for biomarker validation/CDx development, and mentoring junior scientists
Benefits
Comp & perks- Short-term incentive bonuses
- Equity-based awards for salaried roles
- Qualified retirement programs
- Paid time off, including vacation, holiday, and leaves
- Health coverage
- Dental coverage
- Vision coverage
- Flexible working arrangements alongside the expectation of office attendance
- Disability or special-needs accommodation