Principal Software Engineer

Baylor Genetics

. Lead the architecture, design, and development of complex software systems and platforms .

Posted 10/23/2026full-timeRemote • United StatesLeadWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in software architecture, design, and development of complex systems, with a strong focus on C#, .NET, and React + TypeScript applications. Proven ability to mentor engineers, drive technical initiatives, and ensure compliance with regulatory standards in healthcare and clinical environments.

Highest-signal resume keywords

C# Programming.NET FrameworkReact + TypeScript Application DevelopmentRelational Database ManagementSoftware Architecture

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Software EngineeringRESTful API DesignSystem DesignPerformance TuningData ModelingDevOps PrinciplesCI/CD PipelinesCloud-Native ArchitectureRoot-Cause AnalysisTechnical Mentorship

Soft Skills

Analytical SkillsProblem-SolvingCollaborationInfluencing Decision-MakingContinuous Learning

Tools & Technologies

MS SQL ServerPostgreSQLMySQLLIMS SystemsClinical Reporting Platforms

Industry Keywords

HealthcareClinical DiagnosticsGenomicsNGS EnvironmentsRegulated EnvironmentsCLIACAPHIPAA

Tech Stack

Tools & technologies

CloudDistributed SystemsMS SQL ServerMySQLPostgresReactSQLTypeScript.NET

About the role

Key responsibilities & impact

Lead the architecture, design, and development of complex software systems and platforms
Define and champion engineering standards, best practices, and long-term technical roadmaps
Collaborate with cross-functional teams to translate business needs into scalable, secure, and maintainable solutions
Conduct deep technical reviews and guide system design discussions
Ensure architectural consistency across teams
Mentor and coach engineers, fostering technical excellence and continuous learning
Drive root-cause analysis and resolution of complex technical issues
Ensure system reliability and data integrity
Evaluate emerging technologies and guide strategic adoption
Partner with product, laboratory, and bioinformatics teams to optimize workflows and operational efficiency
Ensure compliance with security, privacy, and regulatory requirements
Contribute to innovation initiatives advancing Baylor Genetics’ digital capabilities and competitive advantage
Perform other duties as assigned
Comply with company policies, procedures, and applicable regulatory requirements

Requirements

What you’ll need

B.S. in Computer Science or related field required
10+ years of professional software engineering experience, including significant experience in large-scale or complex systems
Expert-level proficiency with C# and .NET, including .NET Core / .NET 6+
Extensive experience architecting and building React + TypeScript applications
Deep expertise with relational databases such as MS SQL Server, PostgreSQL, or MySQL, including schema design, performance tuning, and data modeling
Proven experience designing, implementing, and governing RESTful APIs and distributed systems
Strong background in software architecture, system design, and engineering best practices
Demonstrated experience leading technical initiatives, mentoring engineers, and influencing cross-functional decision-making
Strong understanding of DevOps principles, CI/CD pipelines, and cloud-native architectures
Excellent analytical and problem-solving skills with the ability to navigate ambiguity and complexity
Equivalent combination of education and experience may be considered
Experience in healthcare, clinical diagnostics, genomics, or NGS environments preferred
Familiarity with laboratory workflows, LIMS systems, or clinical reporting platforms preferred
Experience working in regulated environments such as CLIA, CAP, or HIPAA preferred
Background in designing secure, compliant, and audit-ready systems preferred
Experience with high-performance or data-intensive applications, including optimization and scalability strategies preferred

Benefits

Comp & perks

Remote work arrangement
Equal opportunity and inclusive workplace
Reasonable accommodation during the application process