Medical Director, US Medical Affairs

Cytokinetics

. Support the ongoing development of aficamten .

Posted 10/30/2026full-timeSouth San Francisco • California • United StatesLead💰 $276,120 - $322,140 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in Medical Affairs with a focus on hypertrophic cardiomyopathy, including the development and execution of medical strategies, evidence generation, and cross-functional collaboration. Proficient in managing medical programs, vendor relationships, and aligning medical objectives with organizational strategy.

Highest-signal resume keywords

MD/DO Or PharmD3-5 Years Of Medical Affairs ExperienceCardiovascular Training And Clinical ExperienceKnowledge Of Medical Affairs StrategyStrong Project Management Skills

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Medical Strategy DevelopmentEvidence GenerationClinical Trial Data EvaluationBiostatisticsEpidemiologyVendor ManagementBudget ManagementMedical EducationScientific CommunicationsProduct Launch Experience

Soft Skills

Excellent Oral Communication SkillsExcellent Written Communication SkillsStrong Presentation SkillsAbility To Work IndependentlyAbility To Work In A Team

Tools & Technologies

Microsoft Office

Certifications & Qualifications

MD/DO Or PharmD

Industry Keywords

Hypertrophic CardiomyopathyMedical AffairsPharmaceutical IndustryOPDPPhRMA CodeRegulatory ComplianceClinical ResearchReal-World EvidenceKOL EngagementCongress Strategy

About the role

Key responsibilities & impact

Support the ongoing development of aficamten
Assist in developing and executing medical strategy, including the US Plan of Action
Serve as a medical and scientific expert for hypertrophic cardiomyopathy
Educate healthcare professionals regarding aficamten’s clinical profile and place in HCM therapy
Provide medical leadership throughout development, launch readiness, and lifecycle management
Execute medical launch activities
Provide medical input into cross-functional, brand, evidence generation, market access, and lifecycle management plans
Provide medical expertise and input for REMS activities
Partner with Clinical Development, Commercial, Regulatory, Safety, HEOR, Market Access, and Legal/Compliance teams
Support scientific congress strategy, advisory boards, field force training, medical information response letters, health economics and epidemiology analyses, and marketing and policy projects
Collaborate with regional and global colleagues to align strategy and address local stakeholder needs
Participate in cross-functional Medical and Commercial teams to inform brand strategies and tactics
Provide input into HCM medical education, grant, and sponsorship review and evaluate initiative metrics
Manage medical programs, vendors, timelines, budgets, contracts, and performance measures
Provide clinical and scientific support for healthcare professional inquiries
Support Medical Affairs review of medical and promotional scientific materials through MLR
Participate in integrated evidence plan strategy, identify evidence gaps, and contribute to evidence generation including real-world evidence and investigator-sponsored research
Collaborate with Field Medical Affairs on scientific priorities, training plans, insights, and stakeholder engagement strategy
Analyze field medical insights to inform medical, evidence generation, and educational strategy
Support field material development and healthcare professional inquiries
Assist in field medical education for emerging aficamten data and HCM topics
Build and maintain an active US KOL HCM expert network
Engage hypertrophic cardiomyopathy external experts in scientific exchange

Requirements

What you’ll need

MD/DO or PharmD required
3-5 years of Medical Affairs experience required
Prior pharmaceutical industry and Medical Affairs Medical Director experience
Cardiovascular training and clinical experience strongly preferred
Knowledge of Medical Affairs strategy, including evidence generation, scientific communications, and external engagement strongly preferred
Prior experience with product approvals, launch, and peri-launch activities highly desirable
Background in academic medicine, clinical research, and familiarity with biostatistics and epidemiology highly desirable
Experience with management of vendors, budgets, and strategic timelines a plus
Experience developing medical plans and aligning medical objectives with broader product and organizational strategy a plus
Familiarity with OPDP, PhRMA code, and key regulations in the pharmaceutical industry a plus
Ability to critically evaluate and interpret clinical trial data, peer-reviewed literature, treatment guidelines, and real-world evidence
Ability to work independently and as a member of an integrated, interdisciplinary team
Ability to translate complex scientific information into clear, accurate, and actionable medical guidance
Strong project management skills, including ability to manage multiple priorities, budgets, vendors, timelines, and deliverables
Working knowledge of congress strategy, advisory boards, medical education, and scientific communications
Excellent oral, written, presentation, and executive communication skills
High level of scientific integrity, sound medical judgment, professionalism, and commitment to patient benefit
Proficiency with Microsoft Office
Ability to travel approximately 30% of the time

Benefits

Comp & perks

Equity in the form of stock options and/or restricted stock units
Comprehensive health, dental, vision, life and disability insurance coverage
401k retirement benefits with employer match
Learning stipends
Wellness stipends
Paid time off