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Advisor – Mixed Modality Scientist, Oligonucleotide – Process Translation and Execution
Eli Lilly and Company. Set strategy and technical direction for oligonucleotide process transfers across programs .
Posted 9/17/2026full-timeLebanon • United StatesJuniorMid-Level💰 $130,500 - $211,200 per yearWebsite
Core Competencies
Role fitCore Competencies
Use this summary to align your resume positioning with the role.
Demonstrates expertise in oligonucleotide process development, including synthesis, purification, and scale-up methodologies, while ensuring compliance with cGMP standards. Proven ability to lead cross-functional teams, mentor scientists, and drive process improvements through data analysis and strategic recommendations.
Highest-signal resume keywords
Oligonucleotide Process DevelopmentSynthesis And Purification TechniquesCGMP ComplianceAnalytical Techniques (HPLC/UPLC, LC-MS, GC)Technical Documentation Management
ATS Keywords
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Hard Skills
Oligonucleotide SynthesisPreparative ChromatographyTFF (Tangential Flow Filtration)LyophilizationRoot Cause AnalysisProcess Scale-UpBatch Record CreationData AnalysisProcess QuantificationAseptic Processing
Soft Skills
Excellent Communication SkillsProject LeadershipTeam CollaborationProblem-SolvingAbility To Manage Ambiguity
Tools & Technologies
Larger Sized ReactorsPreparative ColumnsAnalytical EquipmentProcess Engineering ToolsDefinitive Lab Trials
Industry Keywords
Biopharmaceutical ManufacturingProcess EngineeringTechnical ServicesOligonucleotide Unit OperationsCross-Functional Collaboration
About the role
Key responsibilities & impact- Set strategy and technical direction for oligonucleotide process transfers across programs
- Serve as escalation point for complex troubleshooting and technology adoption decisions
- Define scale-up approach for synthesis and purification methods from early-phase process R&D
- Serve as technical authority on oligonucleotide unit operations, including solid phase synthesis, preparative chromatography, TFF, and lyophilization
- Partner with safety and process engineering leadership to shape procedure evaluation standards and approve high-risk or novel procedures
- Translate analytical data into strategic technical recommendations for program and site leadership
- Represent process chemistry and technical challenges to senior leadership and cross-functional stakeholders
- Set standards for plant readiness assessment across synthesis, cleavage, purification, TFF, and lyophilization
- Establish frameworks for use-tests and Definitive Lab Trials confirming plant readiness
- Own technical quality and consistency of documentation, including tech transfer plans, SOPs, batch records, campaign summary reports, and deviation reports
- Drive site-wide process improvement and adoption of new technologies or procedures
- Lead complex process investigations and CAPAs
- Partner with CMC, Product R&D, Manufacturing, and Quality leadership
- Mentor principal and senior scientists and inform PTE training standards
Requirements
What you’ll need- B.S., M.S., or Ph.D. in Chemistry, Biochemistry, Chemical/Biochemical Engineering, or a related discipline
- B.S. with 20+ years, M.S. with 15+ years, or Ph.D. with 2+ years of experience in Oligonucleotide Product/Process Development, Manufacturing Technical Services, or related functional roles
- Strong knowledge of oligonucleotide process, including synthesis, cleavage & deprotection, chromatography, conjugation, and aseptic processing
- Ability to analyze data, perform root cause analysis, and resolve complex technical challenges
- Understanding of biopharmaceutical manufacturing principles and cGMP requirements
- Success in cross-functional, dynamic, and matrixed environments
- Excellent written and verbal communication skills for technical report writing, presentations, and team collaboration
- Experience leading small projects, coordinating activities, and managing timelines
- Experience with oligo synthesis and purification techniques used for developing and scaling-up process reactions
- Comfort working with larger sized reactors and preparative columns, TFF, and related equipment
- Experience creating batch records and conducting scale-up experiments according to those records
- Ability to prioritize multiple activities and manage ambiguity
- Experience with analytical techniques including HPLC/UPLC, LC-MS, and GC
- Process quantification and acquiring mass balance for products and by-products
- Ability to work in manufacturing and laboratory environments
Benefits
Comp & perks- Company bonus depending in part on company and individual performance
- Company-sponsored 401(k)
- Pension
- Vacation benefits
- Medical, dental, vision, and prescription drug benefits
- Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
- Life insurance and death benefits
- Time off and leave of absence benefits
- Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities