Advisor/Sr. Advisor – Bioconjugation Scientist

Eli Lilly and Company

. Facilitate transfer of bioconjugation chemical processes for ADCs and similar modalities from development laboratories to pilot plant, kilo-scale, and production environments .

Posted 10/15/2026full-timeLebanon • United StatesSenior💰 $129,000 - $209,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in bioconjugation chemistry and technology transfer for ADCs, with a strong focus on cGMP manufacturing processes and analytical methods. Proven ability to mentor junior scientists and collaborate cross-functionally to resolve complex technical challenges.

Highest-signal resume keywords

Bioconjugation ChemistryCGMP ManufacturingAnalytical Methods (RP-HPLC, SEC, LC-MS)Technology TransferMentoring and Supervision

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Bioconjugation ChemistryAnalytical MethodsSynthetic Chemistry TechniquesProcess QuantificationBatch Record CreationChromatography SystemsConjugation StrategiesSafety EvaluationRoot Cause AnalysisData Analysis

Soft Skills

Excellent Communication SkillsAbility to Manage AmbiguityCollaborationMentoringProblem Solving

Tools & Technologies

Single-Use Bioprocessing SystemsLiquid ChromatographyTFF OperationsDefinitive Lab TrialsAnalytical Data Documentation

Industry Keywords

ADCsCGMPChemical EngineeringBiochemistryChemical Biology

About the role

Key responsibilities & impact

Facilitate transfer of bioconjugation chemical processes for ADCs and similar modalities from development laboratories to pilot plant, kilo-scale, and production environments
Enable transition to early-phase cGMP manufacturing of gram-to-kilogram API quantities for clinical trial supply
Guide more junior scientists and mentor less experienced scientists
Collaborate cross-functionally with engineers, analytical chemists, chemical technicians, safety, and quality representatives
Receive chemistry from early-phase process research and development laboratories
Evaluate safety of incoming procedures with safety and process engineering groups
Ensure raw material and reagent readiness and obtain reference materials
Participate in setting up analytical methods and reprocess and analyze analytical data
Summarize and present chemistry and technical challenges
Perform familiarization reactions, including reduction, conjugation, and oxidation reactions, and TFF operations
Perform raw-material use tests and document Definitive Lab Trials to confirm plant readiness
Maintain detailed lab notebooks with chemistry descriptions, observations, and organized analytical data
Author and review technical transfer plans, SOPs, batch records, campaign summary reports, and deviation reports
Identify process improvements and implement new technologies or procedures
Support troubleshooting, process deviations, quality events, and non-conformances
Collaborate on root cause analyses and develop corrective and preventive actions (CAPAs)

Requirements

What you’ll need

B.S. or M.S. with 6+ years of experience, or PhD with 2+ years of experience, in manufacturing environments involving biochemistry, chemical biology, conjugation chemistry, chemical engineering, or related field
Experience performing bioconjugation chemistry to form ADCs, including antibody preparation, buffer exchanges, and protein-specific characterization
Hands-on experience across multiple conjugation strategies, including maleimide, click, and enzymatic
Experience working with highly potent molecules and containment in laboratory and production environments
Experience working with single-use bioprocessing systems
Working knowledge of organic chemistry, mechanisms, and reaction improvement and optimization
Knowledge of and hands-on experience with analytical methods including RP-HPLC, SEC, IEX, HIC, LC-MS, and CE-SDS
Hands-on experience with liquid chromatography, bioconjugate purification, and chromatography systems
Experience with synthetic chemistry techniques for developing and scaling up chemical reactions
Experience creating batch records and conducting scale-up experiments according to those records
Experience with process quantification and acquiring mass balance for products and by-products
Demonstrated ability to independently lead technology transfer from development lab to clinical manufacturing
Ability to mentor less experienced scientists and supervise colleagues
Ability to prioritize multiple activities and manage ambiguity
Excellent written and verbal communication skills
Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges
Ability to work cross-functionally with engineers, analytical chemists, chemical technicians, safety, and quality representatives
Ability to work in manufacturing and laboratory environments
Limited domestic and international travel of less than 5% may be required

Benefits

Comp & perks

Company bonus depending, in part, on company and individual performance
Company-sponsored 401(k)
Pension
Vacation benefits
Medical benefits
Dental benefits
Vision benefits
Prescription drug benefits
Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
Life insurance and death benefits
Time off and leave of absence benefits
Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities
Employee resource groups (ERGs) offering support networks