Mixed Modality Advisor – Process Translation and Execution

Eli Lilly and Company

. Evaluate and facilitate transfer of peptide upstream manufacturing processes from development laboratories to pilot plant operations, including kilo-scale and isolator production environments .

Posted 11/10/2026full-timeLebanon • United StatesJuniorMid-Level💰 $130,500 - $211,200 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in peptide chemistry and manufacturing processes, including solid phase peptide synthesis (SPPS) and analytical techniques such as HPLC and LC-MS. Proven ability to lead technology transfer, troubleshoot production issues, and collaborate cross-functionally to ensure successful scale-up and compliance with cGMP standards.

Highest-signal resume keywords

Peptide Chemistry ExpertiseSolid Phase Peptide Synthesis (SPPS)Analytical Techniques (HPLC, LC-MS)Technology Transfer and DocumentationProcess Improvement and Troubleshooting

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Peptide Upstream ManufacturingSynthetic Chemistry TechniquesBatch Record CreationProcess QuantificationData Analysis and Root Cause Analysis

Soft Skills

Excellent Written and Verbal CommunicationCross-Team Collaboration

Tools & Technologies

HPLCUPLCLC-MSGCNMR

Industry Keywords

CGMP ManufacturingPeptide Downstream PurificationLyophilizationChemical EngineeringAnalytical Methods

About the role

Key responsibilities & impact

Evaluate and facilitate transfer of peptide upstream manufacturing processes from development laboratories to pilot plant operations, including kilo-scale and isolator production environments
Enable transition to early-phase cGMP manufacturing of gram-to-kilogram quantities of API for clinical trial supply
Oversee transfer of new peptide processes from development to manufacturing and ensure scalability and process fit to the plant
Troubleshoot production issues and implement new technologies or procedures
Assess peptide synthetic routes from early-phase process research and development laboratories
Perform peptide upstream procedures including SPPS and cleavage and precipitation
Evaluate safety of incoming procedures with safety and process engineering groups
Order and stage chemicals
Obtain reference materials and participate in setting up analytical methods
Reprocess and analyze analytical data to support fact-based decisions
Summarize and present chemistry and technical challenges
Lead familiarization executions for SPPS and cleavage and precipitation to ensure plant readiness
Perform raw-material use tests and document Definitive Lab Trials to confirm plant readiness
Author and review technical documents, including technology transfer plans, SOPs, batch records, campaign summary reports, and deviation reports
Lead process improvement, troubleshooting, and investigations involving deviations, quality events, and non-conformances
Collaborate on root cause analyses and develop corrective and preventive actions (CAPAs)

Requirements

What you’ll need

B.S., M.S., or Ph.D. in chemistry, chemical engineering, or related field
B.S. with 8+ years, M.S. with 5+ years, or Ph.D. with 2+ years of experience in peptide chemistry and/or manufacturing environments involving synthetic peptide API or drug substance
Solid phase peptide synthesis preferred
Strong knowledge of peptide chemistry and mechanisms and application to reaction improvement and optimization
Experience with synthetic chemistry techniques used for developing and scaling up chemical reactions
Proficiency with synthesis of peptide crude via solid phase peptide synthesis and cleavage & deprotection
Comfortable working with larger sized equipment
Experience creating batch records and conducting scale-up experiments according to those records
Experience with analytical techniques including HPLC/UPLC, LC-MS, GC, and NMR
Experience with process quantification and acquiring mass balance for products and by-products
Excellent written and verbal communication skills for technical report writing, presentations, and cross-team collaboration
Familiarity with peptide downstream purification, TFF, lyophilization, precipitation, and safe handling of solids/dry end processing
Ability to analyze data, perform root cause analysis, and resolve complex technical challenges
Ability to work cross-functionally with engineers, analytical chemists, chemical technicians, safety, and quality representatives
Ability to work in manufacturing and laboratory environments
Limited domestic and international travel of less than 5% may be required

Benefits

Comp & perks

Company bonus depending, in part, on company and individual performance
Company-sponsored 401(k)
Pension
Vacation benefits
Medical benefits
Dental benefits
Vision benefits
Prescription drug benefits
Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
Life insurance and death benefits
Time off and leave of absence benefits
Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities