Mixed Modality, Oligonucleotide Scientist

Eli Lilly and Company

. Evaluate and facilitate transfer of oligonucleotide manufacturing processes from development laboratories to pilot plant operations, including kilo-scale and isolator production environments .

Posted 9/20/2026full-timeLebanon • United StatesSeniorLead💰 $67,500 - $173,800 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in oligonucleotide manufacturing processes, including solid-phase synthesis, chromatography, and cGMP compliance, while effectively leading projects and mentoring team members in a fast-paced environment.

Highest-signal resume keywords

Oligonucleotide Process DevelopmentCGMP ManufacturingAnalytical Techniques (HPLC/UPLC, LC-MS, GC)Process Scale-Up and TroubleshootingTechnical Document Authoring

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Oligonucleotide SynthesisPreparative ChromatographyTFF (Tangential Flow Filtration)LyophilizationData AnalysisRoot Cause AnalysisBatch Record CreationProcess QuantificationMass Balance AcquisitionAseptic Processing

Soft Skills

Excellent Communication SkillsProject CoordinationTime ManagementMentoringProblem-Solving

Tools & Technologies

Larger-Sized ReactorsPreparative ColumnsAnalytical Equipment

Industry Keywords

Biopharmaceutical ManufacturingTechnical ServicesProcess EngineeringClinical Trial SupplySafety Evaluation

About the role

Key responsibilities & impact

Evaluate and facilitate transfer of oligonucleotide manufacturing processes from development laboratories to pilot plant operations, including kilo-scale and isolator production environments
Enable transition to early-phase cGMP manufacturing of gram-to-kilogram quantities of API for clinical trial supply
Oversee transfer of new oligonucleotide processes from development to manufacturing
Ensure scalability and process fit to the plant
Troubleshoot production issues and implement new technologies or procedures
Assess and scale up synthesis and purification methods
Perform oligonucleotide procedures including solid-phase synthesis, preparative chromatography, TFF, and lyophilization
Evaluate safety of incoming procedures with safety and process engineering groups
Analyze analytical data to make fact-based decisions
Summarize and present chemistry and technical challenges
Lead familiarization executions to ensure plant readiness for synthesis, cleavage, purification, TFF, and lyophilization
Perform use-tests of key in-process materials and document Definitive Lab Trials
Author and review technical documents, including tech transfer plans, SOPs, batch records, campaign summary reports, and deviation reports
Lead process-related investigations, assess deviations, and support CAPAs
Collaborate with CMC, Product R&D, Manufacturing, and Quality teams
Provide on-floor support for critical operations
Train and mentor junior scientists and technicians in PTE activities

Requirements

What you’ll need

B.S. or M.S. in Chemistry, Biochemistry, Chemical/Biochemical Engineering, or a related discipline
B.S. with 10+ years or M.S. with 7+ years of experience in Oligonucleotide Product/Process Development, Manufacturing Technical Services, or related functional roles
Authorized to work in the United States on a full-time basis
Strong knowledge of oligonucleotide processes, including synthesis, cleavage and deprotection, chromatography, conjugation, and aseptic processing
Ability to analyze data, perform root cause analysis, and resolve complex technical challenges
Understanding of biopharmaceutical manufacturing principles and cGMP requirements
Experience leading small projects, coordinating activities, and managing timelines
Experience with oligo synthesis and purification techniques used for developing and scaling-up process reactions
Comfortable working with larger-sized reactors, preparative columns, TFF, and related equipment
Experience creating batch records and conducting scale-up experiments
Experience with analytical techniques including HPLC/UPLC, LC-MS, and GC
Ability to perform process quantification and acquire mass balance for products and by-products
Excellent written and verbal communication skills
Ability to prioritize multiple activities and manage ambiguity
Ability to work in manufacturing and laboratory environments

Benefits

Comp & perks

Company bonus depending on company and individual performance
Company-sponsored 401(k)
Pension
Vacation benefits
Medical benefits
Dental benefits
Vision benefits
Prescription drug benefits
Healthcare and/or dependent day care flexible spending accounts
Life insurance and death benefits
Certain time off and leave of absence benefits
Employee assistance program
Fitness benefits
Employee clubs and activities