Process Engineer, Purification

Eli Lilly and Company

. Provide technical assessment and support for drug substance API manufacturing of biologics, oligonucleotides, peptides, and bioconjugates .

Posted 9/23/2026full-timeIndianapolis • United StatesJunior💰 $66,000 - $171,600 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in Chemical Engineering with a focus on drug substance API manufacturing processes, ensuring compliance with cGMP and quality standards. Proficient in process optimization, risk assessment, and technical documentation within a pharmaceutical or biotech environment.

Highest-signal resume keywords

Chemical EngineeringAPI ManufacturingProcess OptimizationDeltaVCGMP Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Process EngineeringRisk AssessmentChromatographyTFF SkidsHeat TransferMass TransferTechnical Report WritingRegulatory SubmissionsProcess Control SystemsLaboratory Design

Soft Skills

Analytical SkillsProblem-SolvingCommunication SkillsTeam CollaborationMentoring

Tools & Technologies

DeltaVOSI-PIDynochemAspenElectronic Lab Notebooks

Industry Keywords

BiologicsOligonucleotidesPeptidesBioconjugatesPharmaceuticalBiotechCMOCGMPQuality SystemHSE

About the role

Key responsibilities & impact

Provide technical assessment and support for drug substance API manufacturing of biologics, oligonucleotides, peptides, and bioconjugates
Develop and sustain process knowledge
Support processes and equipment, optimize processes, and manage equipment capabilities and assets
Perform impact and risk assessments for chromatography skids/columns, TFF skids, and related unit operations
Learn laboratory and plant designs for purification equipment, including automation recipes and procedures
Ensure safety and compliance with company safety policies
Ensure processing equipment complies with internal Quality System requirements, engineering standards, and cGMP requirements
Assess rig fit using technical data packages, modeling, simulations, and/or experimental work to verify heat and mass transfer during plant scale-up
Engage and communicate with HSE, Quality Assurance, Tech Services, Development, Operations, FUME/C&Q, Automation, Maintenance, Environmental Monitoring, and Manufacturing
Author, review, or approve technical reports and regulatory submissions
Maintain records and technical notebooks
Identify and communicate quality issues proactively
Develop or review project plans and timetables

Requirements

What you’ll need

BS or MS in chemical engineering or related discipline
Minimum of 1-4 years of experience in a pharmaceutical, biotech, or CMO environment supporting process engineering of drug substance active pharmaceutical ingredient (API) manufacturing or development
Authorized to work in the United States on a full-time basis
No employer support or sponsorship for work authorization or visas
Deep technical interest and understanding in Chemical Engineering
Ability to work well in a team environment and serve as point of accountability
Experience with DeltaV, OSI-PI, Dynochem, Aspen, and/or electronic lab notebooks
Strong analytical and problem-solving skills
Strong oral and written communication skills for diverse audiences
Ability to work independently and as part of a diverse Process Team
Understanding of process control systems
Creativity to identify improvement opportunities and initiative to implement them
Ability to guide and mentor others through processes
Flexibility to meet business needs

Benefits

Comp & perks

Company bonus depending partly on company and individual performance
Company-sponsored 401(k)
Pension
Vacation benefits
Medical benefits
Dental benefits
Vision benefits
Prescription drug benefits
Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities