Statistical/Population Geneticist – Immunology Research

Eli Lilly and Company

. Lead systematic genetic evidence reviews for existing and emerging immunology drug targets .

Posted 10/28/2026full-timeIndianapolis • Massachusetts • United StatesMid-LevelSenior💰 $153,000 - $246,400 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Expertise in statistical genetics and causal inference methodologies, particularly using Mendelian Randomization, to evaluate drug targets for autoimmune diseases. Proficient in analyzing large-scale population datasets and translating complex genetic findings into actionable insights for drug development.

Highest-signal resume keywords

Ph.D. In Statistical GeneticsMendelian Randomization MethodologyProficiency In RExperience With Large-Scale Population DatasetsImmunology Population Genetics Experience

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Causal InferenceFine-Mapping ApproachesColocalization ApproachesStatistical AnalysisGenetic Instrument Validity AssessmentData InterpretationPopulation-Scale Dataset EvaluationGenetic Evidence ReviewMulti-Omics IntegrationGenotype Dataset Manipulation

Soft Skills

Interdisciplinary CommunicationCritical EvaluationCollaboration

Tools & Technologies

RTidyverseGitPLINKGenetics/Genomics Databases

Industry Keywords

Immunology Drug TargetsGenetic EpidemiologyBiostatisticsPharmaceutical R&DGenetic Evidence Quality

About the role

Key responsibilities & impact

Lead systematic genetic evidence reviews for existing and emerging immunology drug targets
Synthesize GWAS, exome/whole-genome sequencing, and rare-variant data to assess causal support and directionality
Build and maintain target evaluation frameworks scoring genetic evidence quality, effect direction, and development-stage relevance
Interrogate and interpret summary and individual-level data from public and licensed genetic resources to support go/no-go and prioritization decisions
Propose novel drug targets with strong human causal evidence for autoimmune diseases
Make decision-enabling judgments on drug target quality using strong scientific rationale
Design, execute, and critically evaluate evidence from large population-scale datasets using Mendelian Randomization and other methods
Assess genetic instrument validity, pleiotropy, and sensitivity of MR findings
Collaborate with external genetics partners and academic collaborators
Translate complex genetic and statistical findings into clear, decision-relevant summaries
Contribute genetics-informed input to target nomination packages, competitive intelligence, and program strategy documents
Represent the statistical genetics perspective in cross-functional target review forums

Requirements

What you’ll need

Ph.D. in statistical genetics, population genetics, genetic epidemiology, biostatistics, computational biology, or a related quantitative field
Demonstrated experience working on large-scale population datasets
Experience with Mendelian randomization (MR) methodology and causal inference from human genetic datasets
Strong proficiency in R, ideally within a tidyverse-based workflow
Comfort with reproducible, version-controlled analysis using Git
Basic knowledge of PLINK or other tools to manipulate large genotype datasets
Practical experience interrogating large-scale genetics/genomics databases and their APIs
Demonstrated proficiency using fine-mapping and colocalization approaches for GWAS summary statistics
Ability to critically evaluate statistical/analytical pipelines for genetic analysis
Ability to communicate methodological trade-offs to interdisciplinary teams
Experience in immunology/immune-mediated population genetics
Experience integrating multi-omics with genetics data, including pQTL or eqTL analysis
Familiarity with drug target identification/validation criteria and workflows in a pharmaceutical or biotech R&D setting
Experience collaborating with external genetics/data partners or academic consortia

Benefits

Comp & perks

Company bonus depending, in part, on company and individual performance
Company-sponsored 401(k)
Pension
Vacation benefits
Medical benefits
Dental benefits
Vision benefits
Prescription drug benefits
Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities
Employee resource groups (ERGs)