Senior Clinical Trial Manager

Frontier Medicines

. Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.

Posted 9/15/2026full-timeBoston • Massachusetts • United StatesSenior💰 $125,000 - $170,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in Clinical Trial Management, including oversight of CROs, regulatory compliance, and study performance monitoring. Proficient in managing clinical trial documentation and ensuring adherence to ICH-GCP guidelines.

Highest-signal resume keywords

Clinical Trial ManagementCRO ManagementICH-GCP GuidelinesOncology Studies ExperienceRegulatory Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Trial ManagementRegulatory Document ReviewStudy Budget TrackingPerformance Metrics MonitoringProtocol ReviewVendor ManagementFeasibility AssessmentStudy RegistrationTMF Quality AssuranceOperational Challenge Mitigation

Soft Skills

Organizational SkillsProblem-Solving SkillsTime Management SkillsAttention to DetailCollaborative Approach

Tools & Technologies

ClinicalTrials.govDocument RepositoriesClinical Operations TrackersDatabases

Industry Keywords

Clinical TrialsOncologyCRORegulatory RequirementsStudy Closeout

About the role

Key responsibilities & impact

Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.
Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed.
Assist with oversight of CRO and vendor set-up and ensure timely study initiation.
Review site-level regulatory documents and escalate issues to appropriate stakeholders.
Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements.
Identify operational challenges and propose mitigation plans with senior team members.
Assist with review of protocols, informed consent forms, case report forms, and other clinical study documents.
Monitor study performance metrics, timelines, deliverables, and CRO trip reports.
Track study budgets and vendor invoices/change orders and flag discrepancies.
Maintain study registration and updates on ClinicalTrials.gov and other applicable registries.
Coordinate Clinical Trial Team meetings and drive action item follow-up.
Maintain clinical operations trackers, databases, and document repositories.
Provide study updates to internal stakeholders and support enrollment, database lock, and study closeout activities.

Requirements

What you’ll need

Bachelor's degree in a scientific, healthcare, or related field, or an RN, required.
5-7 years of Clinical Trial Manager/SCTM or Clinical Project Management experience.
Experience supporting oncology studies strongly preferred.
Vendor and CRO management experience.
Strong working knowledge of ICH-GCP guidelines and clinical trial regulations.
Excellent organizational, problem-solving, and time management skills, with strong attention to detail.
Strong written and verbal communication skills with a collaborative, team-oriented approach.
Comfortable in a fast-paced, dynamic environment; a proactive, roll-up-your-sleeves mindset.
Legally authorized to work in the United States.

Benefits

Comp & perks

Health Care Plan (Medical, Dental & Vision)
Retirement Plan (401k, IRA)
Life Insurance (Basic, Voluntary & AD&D)
Paid Time Off (Vacation, Sick & Public Holidays)
Family Leave (Maternity, Paternity)
Short Term & Long Term Disability
Training & Development
Free Food & Snacks
Wellness Resources
Stock Option Plan
Competitive total rewards package
Healthcare coverage
401k