Frontier Medicines

Medical Director

• Own end-to-end clinical supply chain strategy for active and upcoming trials.
• Develop and maintain clinical drug supply forecasts and demand plans, translating protocol design, enrollment projections, and dosing regimens into packaging, labeling, and distribution plans.
• Select and manage clinical packaging, labeling, and distribution vendors, including oversight and performance management of CMOs/CPOs and specialty distribution/depot partners.
• Own IRT/IWRS requirements, build, and testing in partnership with Clinical Operations, and serve as the clinical supply lead on IRT vendor management.
• Manage comparator and ancillary supply sourcing, including global sourcing strategies where applicable.
• Oversee cold chain and temperature-controlled logistics, expiry/re-test date management, and label reconciliation across depots and sites.
• Partner with CMC/Technical Operations to align clinical supply timelines with drug substance and drug product manufacturing schedules.
• Ensure compliance with GMP, GCP, and applicable import/export regulations, including serialization and country-specific labeling requirements.
• Support regulatory submissions with clinical supply chain content, including IMPD/IND sections and label text, in partnership with Regulatory Affairs and Quality.
• Manage clinical supply budget, purchase orders, and vendor invoicing in partnership with Finance.
• Build scalable clinical supply chain processes and systems as the clinical portfolio and trial complexity grow.
• Report to the Head of Technical Operations and CMC; partner with CMC, Clinical Operations, Quality, and Regulatory Affairs.

Director, Clinical Supply Chain

Clinical Research

• Support day-to-day activities within one or more clinical trials, including country/site feasibility assessments, site selection, start-up, maintenance, and close-out.
• Serve as a key operational point of contact for CROs and trial sites, identifying and escalating potential issues as needed.
• Assist with oversight of CRO and vendor set-up and ensure timely study initiation.
• Review site-level regulatory documents and escalate issues to appropriate stakeholders.
• Help ensure inspection readiness, TMF quality, and adherence to protocol and regulatory requirements.
• Identify operational challenges and propose mitigation plans with senior team members.
• Assist with review of protocols, informed consent forms, case report forms, and other clinical study documents.
• Monitor study performance metrics, timelines, deliverables, and CRO trip reports.
• Track study budgets and vendor invoices/change orders and flag discrepancies.
• Maintain study registration and updates on ClinicalTrials.gov and other applicable registries.
• Coordinate Clinical Trial Team meetings and drive action item follow-up.
• Maintain clinical operations trackers, databases, and document repositories.
• Provide study updates to internal stakeholders and support enrollment, database lock, and study closeout activities.

Director, Clinical Supply Chain

Senior Clinical Trial Manager