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GSK

Principal – AI Product Management, Portfolio Systems

GSK

. Hunt for high-value AI opportunities across the portfolio management and value-realization lifecycle .

Posted 10/26/2026full-timeUnited StatesSenior💰 $177,750 - $296,250 per yearWebsite

Core Competencies

Role fit
Core Competencies

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Demonstrates extensive experience in AI/ML product strategy and portfolio management within the pharma/life sciences sector, focusing on opportunity identification, business case development, and operational model design. Proven ability to influence cross-functional teams and drive AI initiatives from conception to delivery while ensuring compliance with regulatory standards.

Highest-signal resume keywords
AI/ML Product StrategyPortfolio ManagementBusiness Case DevelopmentOperational Model DesignRegulatory Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills
AI Opportunity IdentificationBusiness Case QuantificationDecision Framework DevelopmentDigital Worker DesignAgentic Systems PrototypingPortfolio Review ManagementData ModelingValue TrackingResource AllocationStakeholder Alignment
Soft Skills
Strategic PartnershipInfluencing Without AuthorityExecutive CommunicationProblem FramingCollaboration
Tools & Technologies
AI PlatformsEngineering ToolsFinancial SystemsUsage TelemetryVersion Control Systems
Industry Keywords
PharmaLife SciencesGxPRegulatory RequirementsData Governance

About the role

Key responsibilities & impact
  • Hunt for high-value AI opportunities across the portfolio management and value-realization lifecycle
  • Develop a global portfolio of AI products ranked by impact, feasibility, and time-to-value
  • Build rigorous business cases quantifying cycle time saved, decisions accelerated, cost avoided, and capacity returned
  • Develop domain pattern recognition in portfolio management workflows and identify AI-shaped problems
  • Own the Enterprise AI opportunity portfolio, including in-flight, queued, and de-prioritized opportunities and decision rationales
  • Build trade-off frameworks, define success metrics, run analysis, and recommend engineering resource allocation
  • Evaluate and reject opportunities that will not produce scalable outcomes
  • Partner strategically with forward deployed, full-stack, and data engineering leads
  • Translate ambiguous business problems into problem statements, prototypes, success metrics, and decision frameworks
  • Shape engagements end-to-end, including scope, success criteria, exit conditions, and scaling pathways
  • Identify re-use and platform leverage and help develop reusable capabilities
  • Design the human-digital split, including digital-worker responsibilities, human oversight, evaluation, and safety
  • Redesign the portfolio operating model around automation, decision rights, gates, cadences, roles, and workflows
  • Build a reusable library of agent skills, prompts, templates, and connectors with versioning and quality standards
  • Instrument real-time portfolio insight using delivery and value data from engineering tools, financial systems, usage telemetry, and AI platforms
  • Run executive conversations and build sponsor coalitions for AI engagements
  • Communicate impact to ELT and the board in terms connected to patients, science, and shareholder outcomes
  • Define Enterprise AI’s value-realization framework and measurement approach
  • Run post-mortems and feed learnings into opportunity selection and engagement design
  • Continuously refine the investment thesis for where AI should and should not be applied at GSK

Requirements

What you’ll need
  • 15 or more years of professional experience across some combination of pharma/life sciences, AI/ML product strategy, and product management or strategy roles in technology-led organizations
  • Track record of taking at least one technology or AI initiative from problem framing through executive funding and into delivery
  • Direct involvement in running or building systems for technology or R&D portfolio management, including intake, prioritization, funding stages, resource allocation, benefits tracking, or portfolio reviews
  • Hands-on work with modern AI/ML concepts, including LLMs, agentic systems, digital workers, the ML lifecycle, and data and evaluation patterns, demonstrated through prototyping
  • Prior responsibility for operating as an individual contributor without direct reports and influencing engineering and business teams through frameworks and documented decision criteria
  • Background in product management or product strategy, including opportunity sizing, roadmap development, prototyping, and stakeholder alignment
  • Track record of designing and shipping digital workers and agentic systems that perform operational work, including orchestration, tool use, evaluation, and production reliability and observability
  • Prior responsibility for designing shared libraries of agent skills, prompts, templates, and connectors, including versioning, quality standards, ownership, and discovery
  • Direct involvement in operating model design, defining decision rights, gates, cadences, roles, and workflows between people and digital workers
  • Working knowledge of instrumenting delivery and value data from engineering tools, financial systems, usage telemetry, and AI platforms, including data modeling and governance
  • Preferred: experience in forward deployed engineering, applied AI, or AI lab/COE roles at a pharma, healthcare, or comparable regulated enterprise
  • Preferred: background in management consulting, value engineering, or corporate strategy with hands-on technology experience
  • Preferred: experience navigating GxP, regulatory, and data-governance requirements in pharma AI deployments
  • Preferred: experience codifying product management and user research practices into AI-native tools and using the command line to automate daily work

Benefits

Comp & perks
  • Annual bonus
  • Eligibility to participate in a share based long term incentive program
  • Health care and other insurance benefits for employee and family
  • Retirement benefits
  • Paid holidays
  • Vacation
  • Paid caregiver/parental and medical leave
  • Accommodation or other assistance to apply, if required