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GSK

Senior Director, Cardiovascular and Cardiometabolic Translational Biology

GSK

. Provide scientific leadership for an existing preclinical and clinical cardiovascular portfolio .

Posted 11/4/2026full-timeUpper Providence • Pennsylvania • United StatesSeniorWebsite

Core Competencies

Role fit
Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates expertise in cardiovascular disease biology, translational strategies, and biomarker development while effectively leading scientific collaborations and aligning stakeholders in a matrix environment.

Highest-signal resume keywords
MD/PhD Or PhD In Relevant Scientific DisciplineExtensive Experience In Preclinical BiologyStrong Knowledge Of Cardiovascular Disease BiologyExperience Developing Translational PackagesProven Track Record Advancing Targets Through Development Milestones

ATS Keywords

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Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills
Human GeneticsMulti-OmicsReverse TranslationBiomarker StrategyClinical Hypotheses DevelopmentTarget Mechanisms UnderstandingTranslational Evidence EvaluationCardiovascular Disease FocusPharmaceutical Industry ExperienceScientific Leadership
Soft Skills
Scientific Thought LeadershipCommunication SkillsPresentation SkillsProblem SolvingManaging Multiple Priorities
Industry Keywords
Cardiovascular PortfolioVascular BiologyCardiometabolic DiseaseRegulatory RequirementsScientific CollaborationsBusiness DevelopmentKey-Opinion-Leader NetworkQuality StandardsMatrix EnvironmentTranslational Planning

About the role

Key responsibilities & impact
  • Provide scientific leadership for an existing preclinical and clinical cardiovascular portfolio
  • Define human-relevant mechanistic hypotheses
  • Drive programs covering cardiovascular, vascular, and cardiometabolic disease biology
  • Develop translational strategies using human genetics, multi-omics, and reverse translation
  • Lead biomarker strategies for target engagement, pharmacodynamics, disease activity, risk stratification, and patient selection
  • Monitor scientific and competitive landscapes and recommend evidence-based actions
  • Align matrix stakeholders on study design, data interpretation, target selection, progression, and translational planning
  • Define critical experiments, success criteria, and go/no-go recommendations
  • Ensure rigor, reproducibility, and fit-for-purpose model selection
  • Mentor project teams through hands-on scientific problem solving
  • Partner with disease-area biology, clinical and translational scientists, biostatistics, DMPK, pathology, safety, and platform teams
  • Identify novel therapies, translational approaches, human-relevant models, and analytical methodologies
  • Contribute to business development opportunity identification, evaluation, and scientific diligence
  • Establish strategic collaborations with academic institutions, CROs, and external experts
  • Build a cardiovascular, respiratory, renal, and metabolic key-opinion-leader network
  • Ensure adherence to policies, regulatory expectations, and quality standards
  • Provide input to portfolio resourcing and external spend planning
  • Build scientific strategy, networks, and future portfolio recommendations for GSK’s cardiovascular capabilities

Requirements

What you’ll need
  • MD/PhD or PhD in a relevant scientific discipline (e.g., Cardiovascular Biology, Cell/Molecular Biology, Genetics, Pharmacology, Immunology, or related field)
  • Extensive experience in preclinical biology and forward and reverse translation
  • Extensive experience in the pharmaceutical or biotechnology industry
  • Strong focus on cardiovascular disease, vascular biology, cardio-renal disease, pulmonary vascular disease, heart failure, fibrosis, inflammation, and/or cardiometabolic disease
  • Deep understanding of target mechanisms and translational evidence required to support early clinical development
  • Ability to operate as a senior individual contributor and scientific thought leader in a matrix environment
  • Experience leading external scientific collaborations and evaluating business development opportunities
  • Proven track record advancing targets and/or therapeutic assets through discovery and early development milestones
  • Experience developing translational packages covering mechanistic rationale, human relevance, biomarker strategy, and clinical hypotheses
  • Strong knowledge of cardiovascular disease biology and its intersection with respiratory, hepatic, renal, inflammatory, fibrotic, and metabolic diseases
  • Travel to scientific conferences and occasional international collaboration meetings
  • Preferred: experience partnering with disease-area and clinical/development leaders, expertise in cardiovascular pathophysiology and related biology, human genetics, multi-omics, computational approaches, business acumen, communication and presentation skills, managing multiple priorities, and knowledge of regulatory requirements

Benefits

Comp & perks
  • Competitive salary
  • Annual bonus based on company performance
  • Healthcare and wellbeing programmes
  • Pension plan membership
  • Shares and savings programme
  • Hybrid working model balancing remote and in-office work
  • Comprehensive benefits program for US employees