Iambic Therapeutics

Artificial Intelligence

• Lead the technical roadmap and day-to-day execution for agentic AI workflows accelerating small-molecule discovery across internal pipelines and external collaborations
• Design, build, and deploy multi-step agentic systems integrating ML-based molecular design with automated decision-making loops for hypothesis generation, compound prioritization, and experimental triage
• Drive efficiency gains in discovery collaborations and enable sustainable, scalable business opportunities
• Co-lead creation of the Iambic Lab of the Future, integrating AI molecular design with high-throughput experimental platforms and automated data-generation pipelines
• Partner with computational, experimental, and data engineering teams to ensure agentic systems are scientifically grounded, technically robust, and operationally adopted
• Represent Iambic's agentic discovery capabilities at scientific conferences, partnership discussions, and with academic collaborators
• Work with senior leadership to develop agentic discovery strategy aligned with platform development, pipeline priorities, and business objectives
• Develop and mentor a high-performing agentic AI team

Principal – Agentic AI

Software Engineer

• Lead the design, development, validation, and maintenance of SAS programs generating SDTM, ADaM, and TLFs
• Ensure compliance with CDISC standards, FDA/EMA regulatory guidelines, and internal SOPs
• Collaborate with Biostatisticians, Data Managers, and Clinical Operations teams to define programming requirements and timelines
• Perform quality control and peer review of deliverables
• Act as the technical subject matter expert on statistical programming
• Mentor junior programmers
• Support preparation of clinical study reports, regulatory submission packages including eCTD and ISS/ISE, and responses to regulatory agencies
• Develop and refine departmental processes, templates, and tools
• Contribute to vendor oversight and provide technical leadership for outsourced programming activities
• Interface and collaborate with data science and machine learning groups to bridge clinical and AI infrastructure
• Support statistical programming activities for clinical trials from Phase I through regulatory submission

Senior Principal Statistical Programmer

Full-stack Engineer

• Partner with computational chemists and machine learning researchers to understand research needs and deliver practical software solutions
• Build and maintain Python applications, libraries, APIs, and command-line tools
• Develop reliable workflows for drug discovery workloads
• Improve orchestration, monitoring, and recovery for workloads on AWS and neo-clouds such as Modal and Lambda
• Integrate scientific applications with shared data, compute, and model services
• Troubleshoot issues and document tools
• Help scientists use tools effectively
• Contribute to design, testing, review, deployment, and production support

Software Engineer I/II – Scientific Computing

Clinical Research

• Serve as the primary Data Management resource on one or more clinical studies from study start-up through database lock and close-out
• Coordinate Data Management activities with sponsors, CROs, and cross-functional teams
• Manage database setup and design, Database UAT, query management, data cleaning, and third-party data reconciliation
• Author and maintain Data Management Plans, Data Review Plans, CRF completion guidelines, data review guidelines, medical coding guidelines, and data transfer agreements
• Oversee CRO and EDC vendor performance and deliverables
• Assist with vendor selection, risk assessment, timeline and resource planning, and issue escalation
• Represent Data Management on project teams, working groups, investigator meetings, and sponsor or health authority inspections and audits
• Ensure application of data standards and CDISC conventions, including CDASH and SDTM
• Contribute to process improvement initiatives, SOPs, and Work Instructions
• Ensure compliance with SOPs, Work Instructions, ICH-GCP, and applicable regulations
• Lead, mentor, and drive high-quality, on-time deliverables

Lead Clinical Data Manager

Director

• Oversee outsourced pharmacovigilance activities and contribute to regulatory and safety deliverables
• Work collaboratively with Quality, Clinical Operations, and Clinical Development to establish and execute safety processes
• Provide day-to-day oversight of internally and externally performed SAE processing
• Coordinate reconciliation of safety information across clinical databases and business partners
• Monitor vendor performance through compliance trends and review of operational deliverables
• Track action items, issues, and corrective actions
• Support implementation, maintenance, and enhancement of safety databases
• Contribute to aggregate safety reports and safety sections of clinical, safety, and regulatory documents
• Coordinate safety data deliverables for aggregate reports, regulatory submissions, and health authority requests
• Review individual and aggregate safety data and identify emerging trends
• Co-author and maintain controlled documents, Safety Management Plans, Safety Data Exchange Agreements, and other inspection-readiness documents
• Support CAPAs, change controls, audits, and regulatory inspections
• Perform responsibilities across all phases of development for oral small-molecule oncology therapies
• Report to the Head of Safety

Principal – Agentic AI

Senior Principal Statistical Programmer

Software Engineer I/II – Scientific Computing

Lead Clinical Data Manager

Associate Director, Drug Safety