Principal Statistical Programmer

ICON plc

. Develop and validate R programs for statistical analysis and reporting of clinical trial data .

Posted 11/9/2026full-timeRemote • Romania, Kenya, Poland, Hungary, Bulgaria, South AfricaLeadWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in R Programming for statistical analysis and reporting of clinical trial data, with a strong understanding of CDISC standards and regulatory compliance. Proven ability to lead programming teams and collaborate effectively with biostatisticians to deliver high-quality statistical outputs.

Highest-signal resume keywords

R ProgrammingStatistical ProgrammingCDISC StandardsClinical Trial Data AnalysisRegulatory Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Statistical AnalysisData ValidationDataset DevelopmentQuality ControlAutomationAnalytical WorkflowsStatistical ReportingProcess ImprovementProgramming ToolsMacros

Soft Skills

Analytical SkillsProblem-SolvingAttention to DetailCommunication SkillsTeam Collaboration

Industry Keywords

Clinical ResearchBiotechnologyPharmaceuticalStatistical OutputsRegulatory SubmissionsClinical Study Reporting

About the role

Key responsibilities & impact

Develop and validate R programs for statistical analysis and reporting of clinical trial data
Lead more than one Statistical Programming team to create, validate and generate statistical outputs, including listings, tables, figures, and CDISC-compliant SDTM and ADaM datasets, including mapping specifications, of low to moderate complexity
Collaborate with biostatisticians to define analysis plans and statistical methods applied to clinical data
Perform quality control and validation of statistical outputs, ensuring accuracy, consistency, and regulatory compliance
Assist in preparing statistical reports, presentations, and publications for regulatory submissions and clinical study reporting
Contribute to process improvements by identifying efficiencies in programming practices, automation, and R-based analytical workflows
Support development, maintenance, and enhancement of standardized R programming tools, macros, and reporting solutions across studies

Requirements

What you’ll need

Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or a related quantitative field
8+ years' experience in statistical programming within a clinical research, biotechnology, or pharmaceutical environment
Strong exposure to leading programming activities for clinical studies
Strong proficiency in R programming, including the development and validation of clinical trial datasets, analyses, and reporting outputs
Good understanding of CDISC standards, including SDTM and ADaM, and their application within clinical trials
Familiarity with regulatory requirements and industry guidance related to statistical programming and clinical data reporting
Excellent analytical and problem-solving skills, with a keen attention to detail
Strong communication skills, with the ability to work collaboratively in a team environment and effectively convey complex information
Employment with ICON is contingent upon having the legal right to work in the country where the role is based

Benefits

Comp & perks

Competitive base salary and performance related incentives
Health and wellbeing programmes including medical, dental, and vision coverage where applicable
Retirement and pension plans
Life assurance and disability coverage
Employee assistance programmes and wellbeing resources
Learning and development opportunities through structured training and career pathways