Senior Clinical Trial Manager

ICON plc

. Lead the operational delivery of assigned clinical trials, ensuring milestones, timelines, budget expectations, and quality standards are achieved .

Posted 10/2/2026full-timeRemote • Pennsylvania • United States, CanadaSeniorWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in leading clinical trial operations, ensuring compliance with ICH-GCP guidelines and regulatory requirements while effectively managing timelines, budgets, and stakeholder relationships. Proven ability to identify risks and implement solutions for successful study delivery.

Highest-signal resume keywords

Clinical Trial ManagementICH-GCP ComplianceStudy ExecutionRisk MitigationStakeholder Relationship Management

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Trial OperationsStudy Start-Up ActivitiesSite ActivationEnrollment StrategiesMonitoring ActivitiesBudget ManagementPerformance Metrics ReviewDatabase LockOperational Challenge ResolutionGlobal Clinical Trials Management

Soft Skills

LeadershipCollaborationMentoringProblem-SolvingCommunication

Industry Keywords

Life SciencesHealth SciencesPharmaceuticalBiotechnologyCROClinical Research AssociatesRegulatory RequirementsStudy Oversight PlansMonitoring StrategiesClinical Metrics

About the role

Key responsibilities & impact

Lead the operational delivery of assigned clinical trials, ensuring milestones, timelines, budget expectations, and quality standards are achieved
Drive study start-up activities, site activation, enrollment strategies, and study execution through database lock
Provide oversight of study progress, monitoring activities, clinical metrics, and site performance
Develop and implement effective study oversight plans, monitoring strategies, and risk mitigation approaches
Identify operational challenges and proactively implement solutions to ensure successful study delivery
Build and maintain strong relationships with sponsors, investigators, vendors, and cross-functional stakeholders
Review study performance metrics and provide regular status updates and reporting
Support, mentor, and collaborate with Clinical Research Associates (CRAs) and other study team members
Ensure all clinical trial activities comply with protocol requirements, ICH-GCP guidelines, and applicable regulatory requirements

Requirements

What you’ll need

Bachelor's degree in Life Sciences, Health Sciences, Nursing, Pharmacy, or another relevant scientific discipline, or an equivalent combination of education and experience
Significant Clinical Trial Management experience within a CRO (preferred), pharmaceutical, or biotechnology environment
Demonstrated ability to successfully lead and deliver clinical studies from start-up through closeout
Strong understanding of clinical trial operations, ICH-GCP, and applicable regulatory requirements
Experience managing study timelines, budgets, vendors, and cross-functional stakeholders
Proven ability to identify risks, solve complex operational challenges, and drive study execution
Prior monitoring experience preferred
Experience managing global and/or complex clinical trials preferred
Ability to travel up to 20%
Legal right to work in the country where the role is based

Benefits

Comp & perks

Competitive base salary and performance related incentives
Health and wellbeing programmes including medical, dental, and vision coverage where applicable
Retirement and pension plans
Life assurance and disability coverage
Employee assistance programmes and wellbeing resources
Learning and development opportunities through structured training and career pathways