Executive Director, Clinical Operations

Immatics

. Serve as operational deputy and strategic partner to the VP, Clinical Operations .

Posted 9/18/2026full-timeRemote • United States, GermanyLead💰 $270,000 - $300,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates extensive experience in leading global clinical operations, including trial management, regulatory compliance, and vendor governance. Proven ability to drive performance, mentor leadership teams, and implement strategic resource planning in a biopharmaceutical environment.

Highest-signal resume keywords

Clinical Operations LeadershipGlobal Clinical Trials ManagementRegulatory Compliance (ICH-GCP, FDA/EMA)CRO/Vendor GovernanceOncology Clinical Research

ATS Keywords

Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills

Clinical Trial ManagementData Management SystemsSample LogisticsSite MonitoringPhase III Trial ExecutionRegulatory Filing PreparationOperational Metrics ImplementationBudget PlanningResource Capacity PlanningBusiness Process Optimization

Soft Skills

Strong Communication SkillsInfluencing SkillsMentoringTeam LeadershipChange Management

Tools & Technologies

CTMSETMFDecentralized Trial Technologies

Industry Keywords

BiotechPharmaceuticalCROOncologyCell TherapyImmuno-OncologyClinical ResearchGlobal SOPsTalent AcquisitionWorkforce Planning

About the role

Key responsibilities & impact

Serve as operational deputy and strategic partner to the VP, Clinical Operations
Lead day-to-day operations of the global Clinical Operations organization and act as primary delegate and decision-maker within established authority matrices
Align Trial/Asset Operations, Site Operations, Biosample Operations, and Clinical Systems into one unified ecosystem
Align sub-functions with corporate development milestones and portfolio timelines
Maintain holistic visibility across the clinical portfolio and manage dependencies, critical paths, and resource constraints
Establish early-warning frameworks to identify, escalate, and mitigate execution issues, protocol deviations, and trial bottlenecks
Mentor clinical operations leads and asset directors while ensuring accountability
Lead and develop the senior clinical operations leadership team; design succession plans and career pathways
Cultivate a unified culture across US and Germany organizational footprints
Drive performance calibration, talent acquisition, workforce planning, and organizational capability mapping
Own portfolio capacity planning, headcount forecasting, and strategic resource deployment
Oversee budget planning, accrual tracking, and financial forecasting
Manage CRO/vendor selection, performance metrics, and governance frameworks
Analyze and recommend insourcing versus outsourcing strategies
Champion continuous improvement, business process optimization, and scalable clinical workflows
Ensure adherence to ICH-GCP, FDA/EMA regulations, and global SOPs
Lead inspection readiness frameworks, internal quality audits, and harmonized global data standards
Implement predictive operational metrics, KPIs, and executive dashboards
Co-architect and execute the future-state operating model for late-stage development and commercialization
Lead enterprise-wide change management, capability integration, and digital/systems evolution, including CTMS, eTMF, and decentralized trial technologies
Design and deploy repeatable organizational systems to eliminate recurring operational friction points

Requirements

What you’ll need

Bachelor’s degree in a scientific, nursing, or business discipline required
15+ years of clinical research experience within a biotech, pharmaceutical, or major CRO environment
7+ years in a senior, multi-functional leadership capacity
Advanced degree (MD, PhD, PharmD, MS, or MBA) preferred
Direct operational experience managing Cell Therapy, Immuno-Oncology, or advanced therapeutic modality trials is a strong plus
Experience leading multiple dimensions of clinical operations, including trial management, data/systems, sample logistics, and site monitoring
Extensive experience leading complex, global clinical trials across North America and Europe
Deep experience navigating clinical operations in Oncology required
Proven experience driving Phase III registrational trials, global regulatory filings, and preparing operations for commercialization
Experience leading Clinical Operations within a biopharmaceutical organization with strong understanding of internal clinical operations, trial execution, and regulatory requirements
Sophisticated experience managing large-scale CRO partnerships and vendor governance committees
Strong communication and influencing skills
Applicants must be authorized to work in the United States without the need for current or future sponsorship
Successful completion of a background check, reference checks, and pre-employment drug screening, where permitted by applicable law

Benefits

Comp & perks

Competitive rates for Health, Dental, and Vision Insurance
PTO accrued bi-weekly, with up to 80 hours available to borrow and a maximum accrued balance of 240 hours
12 company paid holidays
10 days of sick time
100% employer-paid life insurance up to 1x annual salary, up to one hundred thousand dollars
100% employer-paid short- and long-term disability coverage
401(k) with immediate eligibility and company match
Partially paid parental leave for eligible employees
Voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, identity theft protection, and pet insurance