Director, Global Value and Health Economics, Outcomes Research

Jazz Pharmaceuticals

. Define and drive global and US payer evidence strategy for pipeline assets from early clinical development through regulatory approval and launch .

Posted 10/31/2026full-timeRemote • Pennsylvania • United StatesLead💰 $212,000 - $318,000 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Expertise in Health Economics and Outcomes Research (HEOR) with a strong focus on payer evidence strategy, economic modeling, and regulatory compliance. Proven ability to lead cross-functional teams and deliver comprehensive evidence packages for market access and launch readiness.

Highest-signal resume keywords

Health EconomicsOutcomes ResearchPayer Evidence StrategyEconomic ModelingMarket Access

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Health Economic ModelingNatural History StudiesGlobal Value DossiersAMCP PIE DossiersStatistical Analysis PlansPhase 2/3 Trial DesignBurden-of-Illness EvaluationsReal-World StudiesEndpoint DevelopmentHTA Submissions

Soft Skills

Exceptional Communication SkillsInfluencing Cross-Functional TeamsMentoring Junior Scientists

Certifications & Qualifications

Master’s Degree in Health EconomicsPhD in Health Economics

Industry Keywords

Biopharmaceutical IndustryManaged CareMarket Access LandscapeGlobal HTA FrameworksRare Disease Drug Development

About the role

Key responsibilities & impact

Define and drive global and US payer evidence strategy for pipeline assets from early clinical development through regulatory approval and launch
Lead global payer evidence generation while serving as the US HEOR lead
Lead US pre-launch HEOR deliverables, payer field enablement tools, and US market access evidence strategies
Translate target product profiles and access ambitions into evidence generation programs, including economic models, natural history studies, Global Value Dossiers, and US AMCP dossiers
Partner with Clinical Development, Biostatistics, and Clinical Operations to integrate payer, formulary, and HTA requirements into Phase 2/3 trial designs
Optimize trial protocols through comparator, inclusion/exclusion criteria, treatment-line, and endpoint recommendations
Integrate PROs, HRQoL, symptom burden scales, and HCRU instruments into pivotal trials
Design rare-disease evidence strategies using natural history data, biomarkers, and external or historical comparators
Architect and lead health economic modeling strategies, including CEAs, BIMs, early conceptual models, and threshold analyses
Direct the design, build, and validation of adaptable global core economic models
Develop US pre-launch evidence roadmaps and lead AMCP PIE dossiers, burden-of-illness dossiers, and US budget impact models
Design payer-facing economic models, evidence decks, and population health tools
Lead HEOR workstreams within Launch Readiness Teams and oversee global launch assets such as GVDs and SLRs
Co-develop EU/INT HTA strategies and analytic packages including ITCs, NMAs, and country model adaptations
Design and execute pre-launch real-world studies, chart reviews, registries, and burden-of-illness evaluations
Serve as a GVHEOR stakeholder in IEGP governance and formulate payer evidence strategies
Develop scientific publication plans, co-author manuscripts, and present findings at major congresses
Mentor junior HEOR scientists, post-doctoral fellows, and matrix colleagues

Requirements

What you’ll need

Required Master’s degree (MSc, MS, MPH, PhD) in Health Economics, Outcomes Research, Pharmacoeconomics, or a closely related quantitative field
Minimum of 7–10 years of experience in HEOR, Global Value, or Health Economics within the biopharmaceutical industry or a top-tier HEOR consulting firm
Proven track record collaborating with Clinical Development, Commercial Development, and Biostatistics teams to influence Phase 2/3 trial design, comparator choice, trial-based resource use collection, and PRO/HRQoL endpoint selection
Strong familiarity with the US managed care and market access landscape, including commercial payers, Medicare Advantage, Medicare Part D/B, Medicaid, and PBMs
Deep understanding of global HTA frameworks, including EU HTA Regulation/JCA, NICE, G-BA, PBAC, and CADTH
Demonstrated capability to lead HEOR launch-readiness workstreams and deliver GVDs, AMCP PIE dossiers, and global ITCs/NMAs under tight regulatory filing timelines
In-depth knowledge of rare disease drug development evidentiary challenges, including natural history studies, registries, surrogate-to-clinical endpoint translation, external control arms, and specialized HTA pathways
Proven ability to define strategic vision and execute and quality-check complex technical models, statistical analysis plans, and dossier sections
Demonstrated success collaborating with regional HEOR teams, particularly EU/INT teams
Ability to influence cross-functional peers and senior leadership across Clinical Development, Medical Affairs, Market Access, and Commercial without formal authority
Exceptional written and verbal communication skills, with an established record of HEOR and clinical publications in peer-reviewed medical and economic journals, or HTA success
Direct experience leading HEOR strategy and deliverables for pipeline assets, including early Phase 2/3 clinical trial protocol integration, endpoint development, and global launch readiness
Experience managing regional trade-offs on evidence needs as part of Phase 2/3 protocol development
Launch lead for at least 2 assets as US HEOR lead or country-level HTA lead
Hands-on experience designing, overseeing, or adapting health economic models
Experience collaborating with regional HEOR teams to deliver evidence packages supporting HTA readiness and submissions

Benefits

Comp & perks

Discretionary annual cash bonus or incentive compensation
Discretionary equity grants
Medical insurance
Dental insurance
Vision insurance
401k retirement savings plan
Flexible paid vacation