Lead Local Operations Manager – Solid Tumor Oncology

Johnson & Johnson

. Own US site-level operational delivery for assigned sites .

Posted 9/25/2026full-timeRemote • Pennsylvania • United StatesSenior💰 $109,000 - $174,800 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Own US site-level operational delivery for assigned sites
Lead and coordinate local trial team activities in compliance with SOPs, procedural documents, and applicable regulations
Lead local project planning to meet recruitment targets and deliver high-quality data on time and within study budget
Develop local trial-specific procedures and tools, recruitment plans, contingency and risk management plans, and budget forecasts
Provide leadership oversight and mentoring support to other Local Operations Managers
Shape US trial operational strategy and integrate site insights into global feasibility and startup planning
Serve as the primary US operational interface to global trial leadership
Monitor country-level operational KPIs and identify systemic risks and mitigation strategies
Act as escalation point for complex site contracting, operational, and recruitment issues
Represent US local operations at investigator or study coordinator site meetings and governance forums
Act as subject matter expert for assigned protocols and develop therapeutic knowledge
Represent Oncology Site Enablement on cross-functional teams
Elevate US site insights to inform global decision-making and continuous improvement
Assume additional Champion or Subject Matter Expert initiatives and lead country, Delivery Unit, or global process initiatives
Travel approximately 10%

Requirements

What you’ll need

A minimum of a bachelor’s degree in Life Sciences, Nursing, Pharmacy, or related scientific discipline (or equivalent experience) is required
Minimum of 4 years of experience in clinical trial operations, trial management, site management, or clinical monitoring
Experience in complex, high-priority, or multi-site trials
Demonstrated experience in oncology trial operations is strongly preferred
In-depth understanding of the clinical development process and end-to-end trial delivery
Expertise in feasibility, startup strategy, enrollment execution, quality oversight, and closeout
Strong knowledge of GCP, regulatory requirements, inspection readiness, and compliance management
Experience supporting audits and regulatory inspections
Leadership experience coaching, mentoring, and guiding Local Operations Managers or site-facing roles
Ability to lead through influence, resolve escalations, and drive alignment across cross-functional and global trial teams
Experience shaping or contributing to country-level or trial-level operational strategy, including site selection, enrollment forecasting, and risk mitigation planning
Strong analytical skills for interpreting country- and site-level KPIs, identifying systemic risks, and implementing corrective actions
Excellent written and verbal communication skills in both the local country language and English
Willingness to travel up to 10%, including overnight stays and participation in investigator meetings and key trial governance meetings
Ability to operate effectively in a highly complex, fast-changing clinical development environment

Benefits

Comp & perks

Consolidated retirement plan (pension)
Savings plan (401(k))
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year; 48 hours for employees residing in Colorado; 56 hours for employees residing in Washington
Holiday pay, including Floating Holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
Inclusive interview process and disability accommodations