Principal Scientist, Clinical Pharmacology, Pharmacometrics

Johnson & Johnson

. Devise clinical pharmacology and model-informed drug development strategies using quantitative methods .

Posted 10/14/2026full-timeUnited StatesLead💰 $117,000 - $201,250 per yearWebsite

Core Competencies

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Core Competencies

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Demonstrates expertise in clinical pharmacology and model-informed drug development, with a strong foundation in pharmacokinetics (PK), pharmacodynamics (PD), and advanced analysis methods. Proficient in regulatory strategy and capable of delivering impactful clinical pharmacology strategies for drug development.

Highest-signal resume keywords

PhD In Pharmaceutical Sciences5+ Years Experience In Pharmaceutical FieldsUnderstanding Of PK, PD, PK/PDModel-Informed Drug Development (MIDD)Proficiency In NONMEM, R, Gastroplus

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical Pharmacology StrategiesPopulation AnalysisModeling And Simulation AnalysesPK/PD AnalysisDose/Exposure-Response RelationshipsPhase I Clinical Pharmacology StudiesRegulatory Document PreparationData IntegrationProduct Differentiation StrategiesScientific Knowledge Contribution

Soft Skills

Good Oral Communication SkillsGood Written Communication SkillsPresentation Skills

Tools & Technologies

NONMEMRGastroplusSimcypWinnonlinMatlab

Industry Keywords

Pharmaceutical R&D ProcessTranslational MedicineRegulatory RequirementsBusiness Development OpportunitiesClinical Pharmacology

About the role

Key responsibilities & impact

Devise clinical pharmacology and model-informed drug development strategies using quantitative methods
Integrate nonclinical data, PK, PD, patient characteristics, disease states, competitive landscape, and drug interactions to support development decisions
Support sub-population, dose, dosage regimen, and study-design selection
Plan, perform, or oversee non-compartmental, population, modeling, and simulation analyses
Analyze preclinical-clinical translation and dose/exposure-response relationships
Plan, summarize, and interpret PK and PK/PD analysis results
Deliver clinical pharmacology strategies for development candidates
Design Phase I clinical pharmacology studies and apply alternate modeling approaches
Manage and/or supervise elements of CPP studies
Develop product differentiation strategies
Define regulatory strategy and prepare CP contributions to regulatory documents
Represent Clinical Pharmacology in external regulatory meetings
Evaluate potential business development opportunities
Contribute to scientific knowledge through publishing, presentations, professional societies, and technical advancement
Manage CP deliverables in accordance with timelines and project goals

Requirements

What you’ll need

PhD, or equivalent degree in Pharmaceutical Sciences, Clinical Pharmacology, Biomedical Engineering, or relevant Biological Sciences
5+ years of experience in pharmaceutical or related fields
Understanding of PK, PD, PK/PD, and/or Translational Medicine
Understanding of advanced analysis methods, including population analysis, PBPK, and QSP
Understanding of modeling tools including NONMEM, R, Gastroplus, Simcyp, Winnonlin, and Matlab
Understanding of model-informed drug development (MIDD) and the overall pharmaceutical R&D process
Working knowledge of regulatory requirements and guidelines
Good oral and written communication skills
Ability to interpret PK and PKPD results and prepare presentations
Willingness to undertake approximately 5% domestic and international travel

Benefits

Comp & perks

Consolidated retirement plan (pension)
Savings plan (401(k))
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year; 48 hours for employees residing in Colorado; 56 hours for employees residing in Washington
Holiday pay, including Floating Holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
Inclusive interview process and disability accommodations