Principal Scientist, Multiomics

Johnson & Johnson

. Develop, validate, and apply next-generation spatial omics and massively parallel functional genomics platforms for therapeutic discovery .

Posted 9/18/2026full-timeCambridge • Massachusetts • United StatesLead💰 $117,000 - $201,250 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in spatial omics, functional genomics, and multiomic data generation, with a strong focus on experimental design, assay development, and technology optimization. Proven ability to lead cross-functional teams and collaborate effectively across biology, technology, and computational science.

Highest-signal resume keywords

PhD In GeneticsSpatial Omics ExpertiseMassively Parallel Reporter Assays (MPRAs)Experimental DesignMultiomics Data Generation

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Assay DevelopmentTechnology OptimizationPooled ScreeningCRISPR-Based Perturbation ScreensSpatial TranscriptomicsSpatial ProteomicsCellular Model GenerationMolecular ProfilingGenetic Screening WorkflowsData Analysis In R And/or Python

Soft Skills

Scientific LeadershipStrong Written CommunicationVerbal Presentation SkillsInnovative Problem SolvingCollaboration

Tools & Technologies

Bruker CosMx10x Genomics VisiumXeniumMicroscopyHigh-Resolution ImagingSequencing Workflows

Industry Keywords

BiotechnologyPharmaceutical IndustryTranslational ResearchBiologics DiscoveryNeuroscienceOncologyImmunology

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Develop, validate, and apply next-generation spatial omics and massively parallel functional genomics platforms for therapeutic discovery
Build and deploy integrated platforms connecting genetic perturbation, genetic element function, cellular phenotypes, and tissue context
Lead experimental workflows spanning perturbation library development, reporter assay engineering, cellular model generation, spatial molecular profiling, and multiomic data generation
Identify regulatory mechanisms, target-effector relationships, disease-associated cellular programs, and therapeutic opportunities
Establish and scale laboratory capabilities as an individual contributor
Evaluate emerging technologies and manage external collaborators and CROs
Serve as a scientific partner supporting multiple discovery programs
Lead development, optimization, and deployment of MPRAs combined with single-cell and spatial omics
Design workflows integrating genetic perturbation, reporter assays, molecular profiling, and spatial analysis
Serve as a subject matter expert in spatial biology, functional genomics, and high-content genomics screening
Design and execute in situ hybridization, microscopy, spatial transcriptomics, spatial proteomics, high-resolution imaging, and sequencing workflows
Develop and optimize spatial assays using Bruker CosMx, 10x Genomics Visium, Xenium, and emerging technologies
Apply spatial approaches to characterize cellular interactions, tissue architecture, disease mechanisms, and therapeutic responses
Develop and deploy MPRAs to investigate protein elements, disease-associated variants, transcriptional control mechanisms, and cell-state-specific regulatory programs
Design and execute pooled functional genomics studies, including CRISPR-based perturbation screens, barcode-enabled assays, and genetic screening workflows
Lead experimental design for library construction, vector engineering, cellular model generation, assay validation, and screening campaigns
Build workflows connecting functional perturbation data with spatial phenotypes and tissue-level biology
Partner with computational scientists on data standards, quality-control frameworks, and scalable analytical pipelines
Collaborate with platform and therapeutic-area scientists to translate multiomic findings into biological insights and therapeutic hypotheses

Requirements

What you’ll need

PhD in Genetics, Genomics, Molecular Biology, Systems Biology, Human Biology, Bioengineering, Computational Biology, or a related discipline
Equivalent industry experience with a strong record of scientific achievement will also be considered
Minimum of 6 years of biotechnology or pharmaceutical industry experience, or equivalent experience in highly technical translational research environments
Demonstrated scientific leadership with a strong record of publications, presentations, patents, or major technology contributions
Deep expertise in spatial omics and molecular imaging technologies, or functional genomics, pooled screening, and massively parallel reporter assays (MPRAs), with demonstrated experience working across both domains
Proven experience in experimental design, assay development, technology optimization, and platform deployment
Experience generating and interpreting complex multiomics datasets
Ability to work effectively across biology, technology, computational science, and therapeutic area teams
Strong written, verbal, and presentation skills
Demonstrated ability to apply innovative approaches to complex biological questions
Familiarity with Antibody structure and Biologics Discovery highly preferred
Postdoctoral training preferred
Preferred experience with spatial transcriptomics, spatial proteomics, single-cell genomics, or multimodal profiling technologies
Preferred experience developing or applying MPRAs, CRISPR screens, Perturb-seq, pooled screening technologies, or regulatory genomics approaches
Preferred familiarity with genomics library design, barcode-based assays, viral vector systems, and cell engineering
Preferred experience with programming and data analysis in R and/or Python
Preferred knowledge of neuroscience, oncology, immunology, or translational research applications
Preferred experience managing multiple collaborations, external partners, and technology evaluations
Ability to serve as a scientific bridge between experimental and computational teams

Benefits

Comp & perks

Consolidated retirement plan (pension)
Savings plan (401(k))
Company long-term incentive program
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year; 48 hours for employees residing in Colorado; 56 hours for employees residing in Washington
Holiday pay, including Floating Holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
Inclusive interview accommodations for applicants with disabilities