Principal Scientist, Preclinical Safety – Translational Pharmacokinetics/Pharmacodynamics

Johnson & Johnson

. Serve as a key member of discovery project teams .

Posted 10/7/2026full-timeUnited StatesLead💰 $117,000 - $201,250 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in pharmacokinetics and pharmacodynamics, with a strong background in mathematical modeling and simulation. Capable of guiding experimental designs and contributing to modeling strategies in drug development.

Highest-signal resume keywords

PhD In PharmacologyPK/PD ModelingMathematical ModelingQuantitative AnalysisInterpersonal Communication

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

PharmacokineticsPharmacodynamicsModel-Based AnalysesPhysiologically-Based Pharmacokinetic ModelingMechanistic PK/PD ModelingSystems Pharmacology ModelingExposure/Response RelationshipsIn Vivo Experimental DesignIn Vitro Experimental DesignQuantitative Modeling

Soft Skills

Organizational SkillsTeamwork SkillsOral CommunicationWritten Communication

Industry Keywords

Drug MetabolismPharmacokinetic StudiesPreclinical StudiesClinical StudiesCandidate SelectionDosing Recommendations

About the role

Key responsibilities & impact

Serve as a key member of discovery project teams
Interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members
Help craft appropriate preclinical and early clinical studies
Conduct associated quantitative model-based analyses to advise candidate selection and dosing recommendations
Apply PK/PD modeling to drive project team decisions from early discovery through early clinical studies
Contribute to modeling and simulation strategies within the organization
Use physiologically-based pharmacokinetic, mechanistic PK/PD, and/or systems pharmacology modeling
Predict preclinical and clinical PK profiles
Quantify exposure/response relationships for target engagement biomarkers, efficacy, and potential adverse effects
Guide in vivo and in vitro experimental designs that are informative for modeling

Requirements

What you’ll need

PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 4+ years of relevant industry experience OR a Master's degree with 6+ years of relevant industry experience is required
Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred
Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications is highly desired
Excellent interpersonal, organizational, oral/written communication and teamwork skills are required

Benefits

Comp & perks

Retirement plan (pension)
Savings plan (401(k))
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year
Holiday pay, including Floating Holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
Inclusive interview process and disability accommodations