Senior Principal Scientist, Data Science RWE

Johnson & Johnson

. Lead a portfolio of real-world evidence projects as a hands-on scientific and technical leader .

Posted 10/13/2026full-timeUnited StatesSenior💰 $137,000 - $235,750 per yearWebsite

Core Competencies

Role fit

Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates expertise in leading real-world evidence projects, applying advanced statistical methods, and utilizing programming skills in R, Python, or SAS to generate actionable insights. Possesses strong knowledge in oncology, immunology, or neuroscience, along with experience in regulatory-grade evidence and communication with regulatory agencies.

Highest-signal resume keywords

Ph.D. In Epidemiology Or BiostatisticsExpert Coding Skills In R, Python, Or SASExtensive Experience With Data Extraction, Cleaning, And AnalysisStatistical Methods To Mitigate Confounding And Selection BiasesSubject Matter Knowledge In Oncology, Immunology, Or Neuroscience

ATS Keywords

Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills

Statistical AnalysisData AnalysisData CleaningStudy Protocol DevelopmentStatistical ProgrammingReal-World Data MethodologiesComparative Effectiveness AnalysisProgramming In RProgramming In PythonProgramming In SAS

Soft Skills

Interpersonal SkillsCommunication SkillsPresentation SkillsMentoring

Tools & Technologies

EHRInsurance ClaimsRegistry Data

Industry Keywords

Real-World EvidenceBiopharmaHealthcareRegulatory-Grade EvidenceClinical Development ProcessDrug Discovery

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Lead a portfolio of real-world evidence projects as a hands-on scientific and technical leader
Develop best practices and mentor team members
Identify common technical requirements for RWE projects
Develop and maintain a common suite of tools to accelerate RWE project delivery
Conceptualize research questions, assess data feasibility, design studies, perform analyses and programming, and interpret results
Develop and apply real-world data methodologies to mitigate observed and unobserved biases in external control arm studies, hybrid control studies, and comparative effectiveness analyses
Generate actionable insights from post-hoc RCT analyses, observational databases, and literature reviews to support regulatory agency interactions
Independently create study protocols, statistical analysis plans, and statistical programming deliverables, including analysis-ready data, tables, and figures
Partner with Data Science Therapeutic Area scientists to conceptualize, lead, shape, and deliver Real-World Evidence

Requirements

What you’ll need

A Ph.D. degree in epidemiology or biostatistics
Expert coding skills using R, Python, or SAS
At least 5 years of relevant experience within biopharma companies, RWE consulting firms, or other relevant healthcare industries
Extensive hands-on experience with data extraction, cleaning, and analysis
Statistical methods to mitigate confounding and selection biases
Expertise with multiple real-world data sources, including EHR, insurance claims, and registry data
Familiarity with clinical trial data structure
Excellent interpersonal, communication, and presentation skills
Familiarity with drug discovery and the clinical development process
Subject matter knowledge in oncology, immunology, or neuroscience
Experience in regulatory-grade evidence and communicating/responding to agency reviews and comments

Benefits

Comp & perks

Consolidated retirement plan (pension)
Savings plan (401(k))
Long-term incentive program
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year; 48 hours for employees residing in Colorado; 56 hours for employees residing in Washington
Holiday pay, including Floating Holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
Inclusive interview process and disability accommodations