Senior Principal Scientist, Data Science RWE

Johnson & Johnson

. Lead a portfolio of real-world evidence projects as a hands-on scientific and technical leader .

Posted 10/13/2026full-timeUnited StatesSenior💰 $137,000 - $235,750 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in leading real-world evidence projects, applying advanced statistical methodologies, and generating actionable insights from diverse data sources. Proficient in coding with R, Python, or SAS, and experienced in regulatory-grade evidence communication within the biopharma industry.

Highest-signal resume keywords

Ph.D. In EpidemiologyExpert Coding Skills In RExpert Coding Skills In PythonExpert Coding Skills In SASExperience With Real-World Data Sources

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Data ExtractionData CleaningData AnalysisStatistical MethodsStudy DesignStatistical Analysis PlansStatistical ProgrammingReal-World Data MethodologiesBias Mitigation TechniquesStudy Protocol Development

Soft Skills

Interpersonal SkillsCommunication SkillsPresentation SkillsMentoring Skills

Industry Keywords

Real-World EvidenceBiopharmaOncologyImmunologyNeuroscienceRegulatory-Grade EvidenceClinical Trial DataExternal Control Arm StudiesComparative Effectiveness AnalysesObservational Databases

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Lead a portfolio of real-world evidence projects as a hands-on scientific and technical leader
Develop best practices and mentor team members
Identify common technical requirements for RWE projects
Develop and maintain a common suite of tools to accelerate RWE project delivery
Conceptualize research questions and conduct data feasibility, study design, analysis, programming, and interpretation for RWE studies
Develop and apply real-world data methodologies to mitigate observed and unobserved biases in external control arm studies, hybrid control studies, and comparative effectiveness analyses
Generate actionable insights from post-hoc RCT analyses, observational databases, and literature reviews to support regulatory agency interactions
Create study protocols, statistical analysis plans, and statistical programming deliverables, including analysis-ready data, tables, and figures
Partner with Data Science Therapeutic Area scientists to conceptualize, lead, shape, and deliver Real World Evidence

Requirements

What you’ll need

Ph.D. degree in epidemiology or biostatistics
Expert coding skills using R, Python, or SAS
At least 5 years of relevant experience within biopharma companies, RWE consulting firms, or other relevant healthcare industries
Extensive hands-on experience with data extraction, cleaning, and analysis
Experience with statistical methods to mitigate confounding and selection biases
Expertise with multiple real-world data sources, including EHR, insurance claims, and registry data
Familiarity with clinical trial data structure
Excellent interpersonal, communication, and presentation skills
Familiarity with drug discovery and the clinical development process
Subject matter knowledge in oncology, immunology, or neuroscience
Experience in regulatory-grade evidence and communicating/responding to agency reviews and comments

Benefits

Comp & perks

Consolidated retirement plan (pension)
Savings plan (401(k))
Long-term incentive program
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year; 48 hours for employees residing in Colorado; 56 hours for employees residing in Washington
Holiday pay, including Floating Holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
Inclusive interview accommodations for applicants with disabilities